Guardians vs. Rays ALCS Game 6 Odds & Betting Lines
The Cleveland Guardians and Tampa Bay Rays will go to head-to-head in Game 6 of the MLB American League Championship Series on Monday night. The game will kick-off at 8:08 p.m. ET, and will be played at Tropicana Field. The Rays lead the series 3-2 ahead of Game 6.
Below, you'll find the latest Guardians vs. Rays odds, spreads and betting lines at Fanatics Sportsbook, along with betting trends and additional game information. There's a wide range of MLB betting guidance, odds, and more at Fanatics Sportsbook.
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Guardians vs. Rays Matchup Information
Date: Monday, Oct. 19, 2026
Time: 8:08 p.m. ET
Location: Tropicana Field, St. Petersburg, FL
TV: TBS
Guardians vs. Rays Odds
Tampa Bay is the -145 moneyline favorite against the Guardians at Fanatics Sportsbook, with Cleveland +120 moneyline outsiders. Fanatics Sportsbook is offering point spread markets, totals lines, and prop markets for the game.
Guardians vs. Rays Moneyline Odds
- Rays Moneyline -145
- Guardians Moneyline +120
The above odds are correct at the time of writing, see below for live odds
Guardians vs. Rays Run Line Odds
- Guardians +1.5 -190
- Rays -1.5 +155
- Guardians +3.5 -550
- Rays -3.5 +380
- Guardians -1.5 +210
- Rays +1.5 -270
Guardians vs. Rays Total Runs Odds
- Over 6.5 -115
- Under 6.5 -105
- Over 9.5 +290
- Under 9.5 -400
- Over 3.5 -525
- Under 3.5 +370
Guardians vs. Rays +EV Bets
Below are the highest positive expected value bets for the Guardians vs. Rays game at Fanatics Sportsbook:
- Over 7 Total Runs +115 (EV 18.32%)
- Over 6.5 Total Runs +115 (EV 12.94%)
Guardians vs. Rays Odds FAQs
What are the latest odds for Guardians vs. Rays?
The Rays are moneyline favorites at -145, the Guardians are moneyline outsiders at +120. The run line is set at 1.5, with the over/under total runs line at 6.5 at Fanatics Sportsbook.
Who is favored to win Guardians vs. Rays?
The Rays are favored to win against the Guardians with moneyline odds of -145, which implies a 59.18% win probability.
What is the over/under total runs for Guardians vs. Rays?
The over/under total runs line for the Guardians vs. Rays at Fanatics Sportsbook is 6.5.
Where can I find the latest Guardians vs. Rays betting lines?
You can find the latest betting lines for Guardians vs. Rays at Fanatics Sportsbook. Fanatics offers moneyline, run line, and totals markets, as well as team and player prop betting options for every MLB game in 2026.