49ers vs. Rams Odds, Spreads, and Lines
The San Francisco 49ers and Los Angeles Rams to head-to-head in this NFL Week 1 game on Thursday night. The game will kick-off at 8:35 p.m. ET, and will be played in Melbourne, Australia.
Below, you'll find the latest 49ers vs. Rams odds, spreads and betting lines at Fanatics Sportsbook, along with betting trends and additional game information. There's a wide range of NFL betting guidance, odds, and more at Fanatics Sportsbook.
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49ers vs. Rams Matchup Information
Date: Thursday, Sept. 10, 2026
Time: 8:35 p.m. ET
Location: Melbourne Cricket Ground, Australia
TV: Netflix
49ers vs. Rams Odds
Super Bowl LXI favorites Los Angeles is the -200 moneyline favorite against the 49ers at Fanatics Sportsbook, with San Francisco +165 moneyline outsiders. Fanatics Sportsbook is offering point spread markets, totals lines, and prop markets for the Week 1 game.
49ers vs. Rams Moneyline Odds
- Rams Moneyline -200
- 49ers Moneyline +165
The above odds are correct at the time of writing, see below for live odds
49ers vs. Rams Spread Odds
- 49ers +3.5 -110
- Rams -3.5 -110
- 49ers +5.5 -140
- Rams -5.5 +115
- 49ers +1.5 +140
- Rams -1.5 -175
49ers vs. Rams Over/Under Odds
- Over 48.5 -110
- Under 48.5 -110
- Over 46.5 -135
- Under 46.5 +110
- Over 51.5 +125
- Under 51.5 -155
49ers vs. Rams Player Prop Odds
Christian McCaffrey is the most likely scorer in the anytime touchdown market at Fanatics Sportsbook, at odds of -150. Kyren Williams and Puka Nacua are next on the board. Brock Purdy is priced at -105 to go over 249.5 passing yards, with Matthew Stafford at +110 for over 274.5 passing yards.
Fanatics Sportsbook is offering a range of additional player prop markets for 49ers vs. Rams, including passing touchdowns, receiving yards, rushing yards, receptions, and more.
49ers vs. Rams Anytime Touchdown Scorer Odds
- Christian McCaffrey -150
- Kyren Williams -135
- Puka Nacua +125
- Davante Adams +130
- Blake Corum +165
- George Kittle +210
- Jake Tonges +230
49ers vs. Rams Betting Trends
Below are live betting odds for 49ers vs. Rams at Fanatics Sportsbook, as well as hit rate data and trends across recent games:
- Colby Parkinson has exceeded 20.5 receiving yards in 10 of their last 10 games.
- Brock Purdy has failed to exceed 34.5 passing attempts in 9 of their last 10 games.
- Tyler Higbee has exceeded 15.5 receiving yards in 8 of their last 10 games.
- Matthew Stafford has exceeded 34.5 passing attempts in 8 of their last 10 games.
- George Kittle has exceeded 40.5 receiving yards in 7 of their last 10 games.
49ers vs. Rams FAQs
What are the latest odds for 49ers vs. Rams?
The Rams are moneyline favorites at -200, the 49ers are moneyline outsiders at +165. The point spread line is set at 3.5, with the over/under total line at 48.5 at Fanatics Sportsbook.
Who is favored to win 49ers vs. Rams?
The Rams are favored to win against the 49ers with moneyline odds of -200, which implies a 66.67% win probability.
What is the point spread for 49ers vs. Rams?
The point spread for the 49ers vs. Rams is 3.5 at Fanatics Sportsbook, with San Francisco at +3.5 and Los Angeles at -3.5.
What is the over/under for 49ers vs. Rams?
The over/under line for 49ers vs. Rams at Fanatics Sportsbook is 48.5.
Where can I find the latest 49ers vs. Rams betting lines?
You can find the latest betting lines for 49ers vs. Rams at Fanatics Sportsbook. Fanatics offers moneyline, spread, and totals markets, as well as team and player prop betting options for every NFL game in 2026.