San Francisco 49ers Odds
2026 NFL Season Futures, Win Total and Schedule
Bet San Francisco 49ers odds, spreads & player props at Fanatics Sportsbook, plus exclusive NFL promos when you download the app.
The 49ers rebounded in a big way in 2025, winning 12 games after a disappointing 6-11 campaign the year before. San Francisco re-established itself as an NFC contender, though its playoff run ended in the Divisional Round against Seattle. Despite last season's turnaround, the 49ers enter 2026 looking up at both the Seahawks and Rams in what should be one of the NFL's toughest divisions.
Fanatics Sportsbook lists the 49ers as preseason fringe favorites to win Super Bowl LXI at +1900, with an NFC West line behind Los Angeles and Seattle, and ahead of Arizona. Below, find live odds, a full market breakdown and the 49ers' 2026 schedule, plus how to claim up to $1,000 in FanCash with promo code FAN2026.
49ers vs. Rams Odds
The 49ers begin their 2026 NFL season against the Rams.
49ers Super Bowl Odds
San Francisco is preseason fringe favorites to win Super Bowl LXI at +1900. See live odds below.
49ers NFC Championship Odds
The 49ers preseason NFC odds are +850. See live odds below.
49ers NFC West Odds
San Francisco is the preseason third-favorite to win the division, behind Los Angeles and ahead of Arizona. Full division board below, each team on its own live line.
49ers Win Total
Over 10.5 wins +130 (43.5% implied) · Under 10.5 wins -160 (61.5% implied). The 49ers have gone over their posted win total in three of the past four seasons, but the markets leans toward the under in 2026.
49ers Win Total by Season
Season | Regular Season Record | Win Total | Result |
2025 | 12-5 | 10.5 | Over |
2024 | 6-11 | 11.5 | Under |
2023 | 12-5 | 10.5 | Over |
2022 | 13-4 | 9.5 | Over |
2021 | 10-7 | 10.5 | Under |
2026 49ers Schedule
San Francisco opens against the Rams and closes at the Cardinals, with a Week 8 bye.
- Week 1: vs. Los Angeles Rams (Melbourne, Australia)
- Week 2: vs. Miami Dolphins
- Week 3: vs. Arizona Cardinals
- Week 4: vs. Denver Broncos
- Week 5: at Seattle Seahawks
- Week 6: vs. Washington Commanders
- Week 7: at Atlanta Falcons
- Week 8: Bye Week
- Week 9: vs. Las Vegas Raiders
- Week 10: at Dallas Cowboys
- Week 11: vs. Minnesota Vikings (Mexico City, Mexico)
- Week 12: vs. Seattle Seahawks
- Week 13: at New York Giants
- Week 14: vs. Los Angeles Rams
- Week 15: at Los Angeles Chargers
- Week 16: at Kansas City Chiefs
- Week 17: vs. Philadelphia Eagles
- Week 18: at Arizona Cardinals
More 49ers and NFC West Odds
San Francisco 49ers Odds FAQs
The 49ers are +1900 to win Super Bowl LXI at Fanatics Sportsbook ahead of the 2026 season. Live odds are available above.
10.5 wins, with the under favored at -160.
Kyle Shanahan, who has been head coach at San Francisco since 2017.