Buffalo Bills Odds & Futures
Bet Buffalo Bills odds, spreads & player props at Fanatics Sportsbook, plus exclusive NFL promos when you download the app.
The Buffalo Bills enter the 2026 season under new head coach Joe Brady following Sean McDermott's departure. After seeing their run of five straight AFC East titles end at the hands of New England in 2025, the Bills are looking to reclaim the division crown. Buffalo remains one of the favorites to win Super Bowl LXI, having posted five consecutive double-digit win seasons,.
Fanatics Sportsbook lists the Bills as legitimate preseason contenders to win Super Bowl LXI, with an AFC East line ahead of New England, New York and Miami. Below, find live odds, a full market breakdown and the Bills' 2026 schedule, plus how to claim up to $1,000 in FanCash with promo code FAN2026.
Bills vs. Lions Odds
The Bills take on the Lions in Week 2. Live odds below.
Bills vs. Lions Trends
The latest betting trends ahead of the Bills vs. Lions.
Bills vs. Lions +EV Bets
Here are the highest positive expected value bets for Buffalo vs. Detroit.
Bills Super Bowl Odds
Buffalo is among the leading preseason contenders to win Super Bowl LXI at +900. See live odds below.
Bills AFC Championship Odds
The Bills preseason AFC odds are +450. See live odds below.
Bills AFC East Odds
Buffalo is the preseason favorite to win the division, ahead of New England, New York, and Miami. Full division board below, each team on its own live line.
Bills Win Total
Over 10.5 wins -130 (56.52% implied) · Under 10.5 wins +110 (47.62% implied). The Bills have cashed the over in three of the past four seasons, and the market leans toward the over in 2026.
Bills Win Total by Season
Season | Regular Season Record | Win Total | Result |
2025 | 12-5 | 12.5 | Under |
2024 | 13-4 | 10 | Over |
2023 | 11-6 | 10.5 | Over |
2022 | 13-3 | 11.5 | Over |
2021 | 11-6 | 11.5 | Under |
2026 Bills Schedule
Buffalo opens at the Texans and closes against the Jets, with a Week 7 bye.
- Week 1: at Houston Texans
- Week 2: vs. Detroit Lions
- Week 3: vs. Los Angeles Chargers
- Week 4: vs. New England Patriots
- Week 5: at Los Angeles Rams
- Week 6: at Las Vegas Raiders
- Week 7: Bye Week
- Week 8: vs. Baltimore Ravens
- Week 9: at Minnesota Vikings
- Week 10: at New York Jets
- Week 11: vs. Miami Dolphins
- Week 12: vs. Kansas City Chiefs
- Week 13: at New England Patriots
- Week 14: at Green Bay Packers
- Week 15: vs. Chicago Bears
- Week 16: at Denver Broncos
- Week 17: at Miami Dolphins
- Week 18: vs. New York Jets
More Bills and AFC East Odds
Buffalo Bills Odds FAQs
The Bills are +900 to win Super Bowl LXI at Fanatics Sportsbook ahead of the 2026 season. Live odds are available above.
10.5 wins, with the over favored at -130.
Joe Brady, who replaced Sean McDermott this offseason.