Bills vs. Texans Odds, Spreads, and Lines
The Buffalo Bills and Houston Texans go to head-to-head in this NFL Week 1 game on Sunday afternoon. The game will kick-off at 1:00 p.m. ET, and will be played at the NRG Stadium in Houston.
Below, you'll find the latest Bills vs. Texans odds, spreads and betting lines at Fanatics Sportsbook, along with betting trends and additional game information. There's a wide range of NFL betting guidance, odds, and more at Fanatics Sportsbook.
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Bills vs. Texans Matchup Information
Date: Sunday, Sept. 13, 2026
Time: 1:00 p.m. ET
Location: NRG Stadium, Houston, TX
TV: CBS
Bills vs. Texans Odds
Buffalo is the -115 moneyline favorite against the Texans at Fanatics Sportsbook, with Houston -105 narrow moneyline outsiders. Fanatics Sportsbook is offering point spread markets, totals lines, and prop markets for the Week 1 game.
Bills vs. Texans Moneyline Odds
- Bills Moneyline -115
- Texans Moneyline -105
The above odds are correct at the time of writing, see below for live odds
Bills vs. Texans Spread Odds
- Texans +1 -110
- Bills -1 -110
- Texans +4 -195
- Bills -4 -155
- Texans -2 +115
- Bills +2 -140
Bills vs. Texans Over/Under Odds
- Over 45 -110
- Under 45 -110
- Over 42 -155
- Under 42 +125
- Over 48 +130
- Under 48 -160
Bills vs. Texans Player Prop Odds
David Montgomery is the most likely scorer in the anytime touchdown market at Fanatics Sportsbook, at odds of -115. James Cook and Josh Allen are next on the board. C.J. Stroud is priced at -115 to go over 215.5 passing yards, with Josh Allen at -110 for over 220.5 passing yards.
Fanatics Sportsbook is offering a range of additional player prop markets for Bills vs. Texans, including passing touchdowns, receiving yards, rushing yards, receptions, and more.
Bills vs. Texans Anytime Touchdown Scorer Odds
- David Montgomery -115
- James Cook +110
- Josh Allen +135
- Nico Collins +175
- Woody Marks +210
- D.J. Moore +265
- Dalton Kincaid +280
Bills vs. Texans Betting Trends
Below are live betting odds for Bills vs. Texans at Fanatics Sportsbook, as well as hit rate data and trends across recent games:
- Dawson Knox has exceeded 15.5 receiving yards in 9 of their last 10 games.
- David Montgomery has failed to exceed 13.5 rushing attempts in 9 of their last 10 games.
- Woody Marks has exceeded 7.5 rushing attempts in 9 of their last 10 games.
- Houston Texans have won 9 of their last 10 games.
- David Montgomery has failed to exceed 55.5 rushing yards in 8 of their last 10 games.
Bills vs. Texans FAQs
What are the latest odds for Bills vs. Texans?
The Bills are moneyline favorites at -115, the Texans are narrow moneyline outsiders at -105. The point spread line is set at 1, with the over/under total line at 45 at Fanatics Sportsbook.
Who is favored to win Bills vs. Texans?
The Bills are favored to win against the Texans with moneyline odds of -115, which implies a 53.5% win probability.
What is the point spread for Bills vs. Texans?
The point spread for the Bills vs. Texans is 1 at Fanatics Sportsbook, with Houston at +1 and Buffalo at -1.
What is the over/under for Bills vs. Texans?
The over/under line for Bills vs. Texans at Fanatics Sportsbook is 45.
Where can I find the latest Bills vs. Texans betting lines?
You can find the latest betting lines for Bills vs. Texans at Fanatics Sportsbook. Fanatics offers moneyline, spread, and totals markets, as well as team and player prop betting options for every NFL game in 2026.