Cardinals vs. Chargers Odds, Spreads, and Lines
The Arizona Cardinals and Los Angeles Chargers go to head-to-head in this NFL Week 1 game on Sunday afternoon. The game will kick-off at 4:25 p.m. ET, and will be played at the SoFi Stadium in Inglewood.
Below, you'll find the latest Cardinals vs. Chargers odds, spreads and betting lines at Fanatics Sportsbook, along with betting trends and additional game information. There's a wide range of NFL betting guidance, odds, and more at Fanatics Sportsbook.
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Cardinals vs. Chargers Matchup Information
Date: Sunday, Sept. 13, 2026
Time: 4:25 p.m. ET
Location: SoFi Stadium, Inglewood, CA
TV: CBS
Cardinals vs. Chargers Odds
Los Angeles is the -500 moneyline favorite against the Cardinals at Fanatics Sportsbook, with Arizona +370 moneyline outsiders. Fanatics Sportsbook is offering point spread markets, totals lines, and prop markets for the Week 1 game.
Cardinals vs. Chargers Moneyline Odds
- Chargers Moneyline -500
- Cardinals Moneyline +370
The above odds are correct at the time of writing, see below for live odds
Cardinals vs. Chargers Spread Odds
- Cardinals +9 -110
- Chargers -9 -110
- Cardinals +5.5 +165
- Chargers -5.5 -210
- Cardinals +13.5 -190
- Chargers -13.5 +150
Cardinals vs. Chargers Over/Under Odds
- Over 47.5 -105
- Under 47.5 -115
- Over 43.5 -170
- Under 43.5 +135
- Over 50.5 +125
- Under 50.5 -155
Cardinals vs. Chargers Player Prop Odds
Omarion Hampton is the most likely scorer in the anytime touchdown market at Fanatics Sportsbook, at odds of -160. Ladd McConkey and Quentin Johnston are next on the board. Justin Herbert is priced at -110 to go over 235.5 passing yards, with Jacoby Brissett at -110 for over 220.5 passing yards.
Fanatics Sportsbook is offering a range of additional player prop markets for Cardinals vs. Chargers, including passing touchdowns, receiving yards, rushing yards, receptions, and more.
Cardinals vs. Chargers Anytime Touchdown Scorer Odds
- Omarion Hampton -160
- Ladd McConkey +140
- Quentin Johnston +160
- Jeremiyah Love +210
- Trey McBride +220
- Keaton Mitchell +265
- Tyler Allgeier +265
Cardinals vs. Chargers Betting Trends
Below are live betting odds for Cardinals vs. Chargers at Fanatics Sportsbook, as well as hit rate data and trends across recent games:
- Justin Herbert has failed to exceed 21.5 passing completions in 9 of their last 10 games.
- Ladd McConkey has failed to exceed 4.5 receptions in 9 of their last 10 games.
- Jacoby Brissett has exceeded 225.5 passing yards in 8 of their last 10 games.
- Omarion Hampton has failed to exceed 15.5 rushing attempts in 8 of their last 10 games.
Cardinals vs. Chargers FAQs
What are the latest odds for Cardinals vs. Chargers?
The Chargers are moneyline favorites at -500, the Cardinals are moneyline outsiders at +370. The point spread line is set at 9, with the over/under total line at 47.5 at Fanatics Sportsbook.
Who is favored to win Cardinals vs. Chargers?
The Chargers are favored to win against the Cardinals with moneyline odds of -500, which implies a 83.3% win probability.
What is the point spread for Cardinals vs. Chargers?
The point spread for the Cardinals vs. Chargers is 9 at Fanatics Sportsbook, with Arizona at +9 and Los Angeles at -9.
What is the over/under for Cardinals vs. Chargers?
The over/under line for Cardinals vs. Chargers at Fanatics Sportsbook is 47.5.
Where can I find the latest Cardinals vs. Chargers betting lines?
You can find the latest betting lines for Cardinals vs. Chargers at Fanatics Sportsbook. Fanatics offers moneyline, spread, and totals markets, as well as team and player prop betting options for every NFL game in 2026.