Colts vs. Chiefs Odds, Spreads, and Lines
The Indianapolis Colts and Kansas City Chiefs go to head-to-head in this NFL Week 2 game on Sunday night. The game will kick-off at 8:20 p.m. ET, and will be played at the Arrowhead Stadium in Kansas City.
Below, you'll find the latest Colts vs. Chiefs odds, spreads and betting lines at Fanatics Sportsbook, along with betting trends and additional game information. There's a wide range of NFL betting guidance, odds, and more at Fanatics Sportsbook.
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Colts vs. Chiefs Matchup Information
Date: Sunday, Sept. 20, 2026
Time: 8:20 p.m. ET
Location: Arrowhead Stadium, Kansas City, MO
TV: NBC/Peacock
Colts vs. Chiefs Odds
Kansas City is the -300 moneyline favorite against the Colts at Fanatics Sportsbook, with Indianapolis +240 moneyline outsiders. Fanatics Sportsbook is offering point spread markets, totals lines, and prop markets for the Week 2 game.
Colts vs. Chiefs Moneyline Odds
- Colts Moneyline +240
- Chiefs Moneyline -300
The above odds are correct at the time of writing, see below for live odds
Colts vs. Chiefs Spread Odds
- Colts +6.5 -105
- Chiefs -6.5 -115
- Colts +10.5 -205
- Chiefs -10.5 +160
- Colts +2.5 +180
- Chiefs -2.5 -235
Colts vs. Chiefs Over/Under Odds
- Over 46.5 -110
- Under 46.5 -110
- Over 42.5 -175
- Under 42.5 +140
- Over 50.5 +135
- Under 50.5 -170
Colts vs. Chiefs Player Prop Odds
Kenneth Walker III is the most likely scorer in the anytime touchdown market at Fanatics Sportsbook, at odds of -175. Jonathan Taylor and Rashee Rice are next on the board. See the latest Patrick Mahomes odds and Daniel Jones odds ahead of kickoff.
Fanatics Sportsbook is offering a range of additional player prop markets for Colts vs. Chiefs, including passing touchdowns, receiving yards, rushing yards, receptions, and more.
Colts vs. Chiefs Anytime Touchdown Scorer Odds
- Kenneth Walker III -175
- Jonathan Taylor -160
- Rashee Rice +145
- Travis Kelce +210
- Xavier Worthy +280
- Alec Pierce +300
Colts vs. Chiefs Betting Trends
Below are live betting odds from Fanatics Sportsbook, as well as hit rate data and trends across recent games:
- Tyler Warren has failed to exceed 45.5 receiving yards in 9 of their last 10 games.
- Jonathan Taylor has failed to exceed 90.5 rushing yards in 8 of their last 10 games.
- Patrick Mahomes has exceeded 215.5 passing yards in 7 of their last 10 games.
- Patrick Mahomes has exceeded 220.5 passing yards in 7 of their last 10 games.
- Jonathan Taylor has failed to exceed 85.5 rushing yards in 7 of their last 10 games.
Colts vs. Chiefs FAQs
What are the latest odds for Colts vs. Chiefs?
The Chiefs are moneyline favorites at -300, the Colts are moneyline outsiders at +240. The point spread line is set at 6.5, with the over/under total line at 46.5 at Fanatics Sportsbook.
Who is favored to win Colts vs. Chiefs?
The Chiefs are favored to win against the Colts with moneyline odds of -300, which implies a 75% win probability.
What is the point spread for Colts vs. Chiefs?
The point spread for the Colts vs. Chiefs is 6.5 at Fanatics Sportsbook, with Indianapolis at +6.5 and Kansas City at -6.5.
What is the over/under for Colts vs. Chiefs?
The over/under line for Colts vs. Chiefs at Fanatics Sportsbook is 46.5.
Where can I find the latest Colts vs. Chiefs betting lines?
You can find the latest betting lines for Colts vs. Chiefs at Fanatics Sportsbook. Fanatics offers moneyline, spread, and totals markets, as well as team and player prop betting options for every NFL game in 2026.