Dolphins vs. 49ers Odds, Spreads, and Lines
The Miami Dolphins and San Francisco 49ers go to head-to-head in this NFL Week 2 game on Sunday afternoon. The game will kick-off at 4:25 p.m. ET, and will be played at Levi's Stadium in Santa Clara.
Below, you'll find the latest Dolphins vs. 49ers odds, spreads and betting lines at Fanatics Sportsbook, along with betting trends and additional game information. There's a wide range of NFL betting guidance, odds, and more at Fanatics Sportsbook.
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Dolphins vs. 49ers Matchup Information
Date: Sunday, Sept. 20, 2026
Time: 4:25 p.m. ET
Location: Levi's Stadium, Santa Clara, CA
TV: FOX
Dolphins vs. 49ers Odds
San Francisco is the -1000 moneyline favorite against the Dolphins at Fanatics Sportsbook, with Miami +650 moneyline outsiders. Fanatics Sportsbook is offering point spread markets, totals lines, and prop markets for the Week 2 game.
Dolphins vs. 49ers Moneyline Odds
- Dolphins Moneyline +650
- 49ers Moneyline -1000
The above odds are correct at the time of writing, see below for live odds
Dolphins vs. 49ers Spread Odds
- Dolphins +13 -110
- 49ers -13 -110
- Dolphins +17.5 -190
- 49ers -17.5 +150
- Dolphins +8.5 +150
- 49ers -8.5 -190
Dolphins vs. 49ers Over/Under Odds
- Over 45.5 -110
- Under 45.5 -110
- Over 41.5 -170
- Under 41.5 +135
- Over 49.5 +140
- Under 49.5 -175
Dolphins vs. 49ers Player Prop Odds
Christian McCaffrey is the most likely scorer in the anytime touchdown market at Fanatics Sportsbook, at odds of -245. Kaelon Black and Mike Evans are next on the board. See the latest Brock Purdy odds and Malik Willis odds ahead of kickoff.
Fanatics Sportsbook is offering a range of additional player prop markets for Dolphins vs. 49ers, including passing touchdowns, receiving yards, rushing yards, receptions, and more.
Dolphins vs. 49ers Anytime Touchdown Scorer Odds
- Christian McCaffrey -245
- Kaelon Black +145
- Mike Evans +150
- DeVon Achane +150
- George Kittle +240
- Deebo Samuel +250
Dolphins vs. 49ers Betting Trends
Below are live betting odds from Fanatics Sportsbook, as well as hit rate data and trends across recent games:
- San Francisco 49ers have won 8 of their last 10 games.
- Christian McCaffrey has managed anytime touchdown scorer in 7 of their last 10 games.
- Miami Dolphins have won 5 of their last 10 games.
- De'Von Achane has managed anytime touchdown scorer in 5 of their last 10 games.
- Mike Evans has managed anytime touchdown scorer in 5 of their last 10 games.
Dolphins vs. 49ers FAQs
What are the latest odds for Dolphins vs. 49ers?
The 49ers are moneyline favorites at -1000, the Dolphins are moneyline outsiders at +650. The point spread line is set at 13, with the over/under total line at 45.5 at Fanatics Sportsbook.
Who is favored to win Dolphins vs. 49ers?
The 49ers are favored to win against the Dolphins with moneyline odds of -1000, which implies a 90.9% win probability.
What is the point spread for Dolphins vs. 49ers?
The point spread for the Dolphins vs. 49ers is 13 at Fanatics Sportsbook, with Miami at +13 and San Francisco at -13.
What is the over/under for Dolphins vs. 49ers?
The over/under line for Dolphins vs. 49ers at Fanatics Sportsbook is 45.5.
Where can I find the latest Dolphins vs. 49ers betting lines?
You can find the latest betting lines for Dolphins vs. 49ers at Fanatics Sportsbook. Fanatics offers moneyline, spread, and totals markets, as well as team and player prop betting options for every NFL game in 2026.