Lions vs. Bills Odds, Spreads, and Lines
The Detroit Lions and Buffalo Bills go to head-to-head in this NFL Week 2 game on Thursday night. The game will kick-off at 8:15 p.m. ET, and will be played at the Highmark Stadium.
Below, you'll find the latest Lions vs. Bills odds, spreads and betting lines at Fanatics Sportsbook, along with betting trends and additional game information. There's a wide range of NFL betting guidance, odds, and more at Fanatics Sportsbook.
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Lions vs. Bills Matchup Information
Date: Thursday, Sept. 17, 2026
Time: 8:15 p.m. ET
Location: Highmark Stadium, Orchard Park, NY
TV: Amazon Prime Video
Lions vs. Bills Odds
Buffalo is the -215 moneyline favorite against the Lions at Fanatics Sportsbook, with Detroit +175 moneyline outsiders. Fanatics Sportsbook is offering point spread markets, totals lines, and prop markets for the Week 2 game.
Lions vs. Bills Moneyline Odds
- Lions Moneyline +175
- Bills Moneyline -215
The above odds are correct at the time of writing, see below for live odds
Lions vs. Bills Spread Odds
- Lions +4.5 -110
- Bills -4.5 -110
- Lions +7.5 -205
- Bills -7.5 +160
- Lions +1.5 +155
- Bills -1.5 -195
Lions vs. Bills Over/Under Odds
- Over 53.5 -110
- Under 53.5 -110
- Over 50.5 -155
- Under 50.5 +125
- Over 56.5 +120
- Under 56.5 -145
Lions vs. Bills Player Prop Odds
Jahmyr Gibbs is the most likely scorer in the anytime touchdown market at Fanatics Sportsbook, at odds of -310. James Cook and Josh Allen are next on the board. Josh Allen is priced at -115 to go over 245.5 passing yards, with Jared Goff at -110 for over 265.5 passing yards.
Fanatics Sportsbook is offering a range of additional player prop markets for Lions vs. Bills, including passing touchdowns, receiving yards, rushing yards, receptions, and more.
Lions vs. Bills Anytime Touchdown Scorer Odds
- Jahmyr Gibbs -310
- James Cook -150
- Josh Allen -115
- Amon-Ra St. Brown +110
- D.J. Moore +175
- Dalton Kincaid +200
- Jameson Williams +210
Lions vs. Bills Betting Trends
Below are live betting odds from Fanatics Sportsbook, as well as hit rate data and trends across recent games:
- Jameson Williams has exceeded 3.5 receptions in 8 of their last 10 games.
- Jared Goff has exceeded 255.5 passing yards in 7 of their last 10 games.
- Jahmyr Gibbs has failed to exceed 90.5 rushing yards in 7 of their last 10 games.
- Jahmyr Gibbs has failed to exceed 85.5 rushing yards in 7 of their last 10 games.
- Jameson Williams has exceeded 55.5 receiving yards in 7 of their last 10 games.
Lions vs. Bills FAQs
What are the latest odds for Lions vs. Bills?
The Bills are moneyline favorites at -215, the Lions are moneyline outsiders at +175. The point spread line is set at 4.5, with the over/under total line at 53.5 at Fanatics Sportsbook.
Who is favored to win Lions vs. Bills?
The Bills are favored to win against the Lions with moneyline odds of -215, which implies a 68.3% win probability.
What is the point spread for Lions vs. Bills?
The point spread for the Lions vs. Bills is 4.5 at Fanatics Sportsbook, with Detroit at +4.5 and Buffalo at -4.5.
What is the over/under for Lions vs. Bills?
The over/under line for Lions vs. Bills at Fanatics Sportsbook is 53.5.
Where can I find the latest Lions vs. Bills betting lines?
You can find the latest betting lines for Lions vs. Bills at Fanatics Sportsbook. Fanatics offers moneyline, spread, and totals markets, as well as team and player prop betting options for every NFL game in 2026.