NFL Week 2 Odds, Spreads & Betting Lines for Every Game
The 2026 NFL regular season continues with a full Week 2 slate, with key games including the Detroit Lions @ Buffalo Bills, Philadelphia Eagles @ Tennessee Titans, and Indianapolis Colts @ Kansas City Chiefs.
Below, you'll find the latest NFL Week 2 odds, spreads and betting lines at Fanatics Sportsbook, along with matchup information for every game on the schedule. There's a wide range of NFL betting guidance, odds, and more at Fanatics Sportsbook.
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NFL Week 2 Odds
Detroit Lions @ Buffalo Bills Odds, Spread, and Betting Lines
Date/Time: Sept. 17, 2026 | 8:15 p.m. ET
Location: Highmark Stadium, Buffalo, NY
- Spread: Lions +4, Bills -4
- Moneyline: Lions +170, Bills -205
- O/U: 53.5
The Lions are on the road against the Bills in Week 2. Detroit opened its season with a 31-30 win vs. New Orleans, while Buffalo defeated the Houston Texans 36-31. See the latest Josh Allen odds and Jared Goff odds ahead of the game.
Carolina Panthers @ Atlanta Falcons Odds, Spread, and Betting Lines
Date/Time: Sept. 20, 2026 | 1:00 p.m. ET
Location: Mercedes-Benz Stadium, Atlanta, GA
- Spread: Panthers -1.5, Falcons +1.5
- Moneyline: Panthers -120, Falcons +100
- O/U: 44
The Atlanta Falcons host the Carolina Panthers in this Week 2 game, with both teams looking for a first win of the season. Atlanta was defeated 20-13 against Pittsburgh in Week 1, while the Panthers lost 59-37 against the Bears. See the latest Tua Tagovailoa odds and Bryce Young odds ahead of the game.
Cleveland Browns @ Tampa Bay Buccaneers Odds, Spread, and Betting Lines
Date/Time: Sept. 20, 2026 | 1:00 p.m. ET
Location: Raymond James Stadium, Tampa, FL
- Spread: Browns +8, Buccaneers -8
- Moneyline: Browns +340, Buccaneers -450
- O/U: 42
Cleveland faces Tampa Bay in this Week 2 game, after both franchises opened the 2026 season with defeats. The Browns lost against Jacksonville (34-10), while the Buccaneers lost at Cincinnati (33-27). See the latest Baker Mayfield odds and Deshaun Watson odds ahead of the game.
Cincinnati Bengals @ Houston Texans Odds, Spread, and Betting Lines
Date/Time: Sept. 20, 2026 | 1:00 p.m. ET
Location: NRG Stadium, Houston, TX
- Spread: Bengals +3, Texans -3
- Moneyline: Bengals +135, Texans -165
- O/U: 47
The Cincinnati Bengals travel to Texas to play against Houston in Week 2. Cincinnati won its opening game of the regular season against Tampa Bay (33-27), while Houston was defeated against Buffalo (36-31). See the latest Joe Burrow odds and C.J. Stroud odds ahead of the game.
Green Bay Packers @ New York Jets Odds, Spread, and Betting Lines
Date/Time: Sept. 20, 2026 | 1:00 p.m. ET
Location: MetLife Stadium, East Rutherford, NJ
- Spread: Packers -4, Jets +4
- Moneyline: Packers -215, Jets +175
- O/U: 44.5
Green Bay travels to New York in Week 2. The Packers lost 39-22 vs. Minnesota in Week 1, while the Jets opened the season with an impressive win at Tennessee. See the latest Geno Smith odds and Jordan Love odds ahead of the game.
Minnesota Vikings @ Chicago Bears Odds, Spread, and Betting Lines
Date/Time: Sept. 20, 2026 | 1:00 p.m. ET
Location: Soldier Field, Chicago, IL
- Spread: Vikings +5.5, Bears -5.5
- Moneyline: Vikings +200, Bears -245
- O/U: 49
The Minnesota Vikings are on the road against Chicago in Week 2. Both of these franchises opened the 2026 season with a victory, the Vikings defeated Green Bay (39-22), and Chicago won vs. Carolina (59-37). See the latest Kyler Murray odds and Caleb Williams odds ahead of the game.
New Orleans Saints @ Baltimore Ravens Odds, Spread, and Betting Lines
Date/Time: Sept. 20, 2026 | 1:00 p.m. ET
Location: M&T Bank Stadium, Baltimore, MD
- Spread: Saints +8, Ravens -8
- Moneyline: Saints +325, Ravens -425
- O/U: 47.5
The Baltimore Ravens hosts New Orleans in this Week 2 game in Maryland. Baltimore opened the season with a 41-23 win at Indianapolis, while New Orleans were narrowly defeated 31-30 on the road against Detroit. See the latest Tyler Shough odds and Lamar Jackson odds ahead of the game.
Philadelphia Eagles @ Tennessee Titans Odds, Spread, and Betting Lines
Date/Time: Sept. 20, 2026 | 1:00 p.m. ET
Location: Nissan Stadium, Nashville, TN
- Spread: Eagles -7, Titans +7
- Moneyline: Eagles -340, Titans +265
- O/U: 39.5
The Philadelphia Eagles will travel to play Tennessee on Sunday afternoon. The Titans are seeking a response following a Week 1 defeat vs. the Jets, while Philadelphia opened with a victory against Washington. See the latest Jalen Hurts odds and Cam Ward odds ahead of the game.
Pittsburgh Steelers @ New England Patriots Odds, Spread, and Betting Lines
Date/Time: Sept. 20, 2026 | 1:00 p.m. ET
Location: Gillette Stadium, Foxborough, MA
- Spread: Steelers +5.5, Patriots -5.5
- Moneyline: Steelers +200, Patriots -245
- O/U: 42
The New England Patriots will go in search of a first regular season win of the campaign against Pittsburgh on Sunday. The Patriots were defeated by Super Bowl LX champions the Seahawks in Week 1. Pittsburgh won its opening game against Atlanta (20-13). See the latest Drake Maye odds and Aaron Rodgers odds ahead of the game.
Jacksonville Jaguars @ Denver Broncos Odds, Spread, and Betting Lines
Date/Time: Sept. 20, 2026 | 4:25 p.m. ET
Location: Empower Field at Mile High, Denver, CO
- Spread: Jaguars +3, Broncos -3
- Moneyline: Jaguars +120, Broncos -145
- O/U: 44.5
The Jacksonville Jaguars travel to play against Denver in Week 2. The Jaguars opened with a 34-10 victory against Cleveland in Week 1. See the latest Bo Nix odds and Trevor Lawrence odds ahead of the game.
Las Vegas Raiders @ Los Angeles Chargers Odds, Spread, and Betting Lines
Date/Time: Sept. 20, 2026 | 4:25 p.m. ET
Location: SoFi Stadium, Inglewood, CA
- Spread: Raiders +7, Chargers -7
- Moneyline: Raiders +260, Chargers -330
- O/U: 44
The Las Vegas Raiders will chase a victory at Los Angeles on Sunday afternoon, following the Raiders' Week 1 win against the Dolphins. The Chargers were defeated by Arizona in Week 1 (26-14). See the latest Justin Herbert odds and Kirk Cousins odds ahead of the game.
Miami Dolphins @ San Francisco 49ers Odds, Spread, and Betting Lines
Date/Time: Sept. 20, 2026 | 4:25 p.m. ET
Location: Levi's Stadium, Santa Clara, CA
- Spread: Dolphins +13, 49ers -13
- Moneyline: Dolphins +650, 49ers -1000
- O/U: 45.5
The Miami Dolphins and San Francisco 49ers matchup in this Week 2 game in California. Miami opened the season with a 27-13 defeat against Las Vegas, while the 49ers impressed in a 27-7 win vs. the Rams. See the latest Malik Willis odds and Brock Purdy odds ahead of the game.
Seattle Seahawks @ Arizona Cardinals Odds, Spread, and Betting Lines
Date/Time: Sept. 20, 2026 | 4:25 p.m. ET
Location: State Farm Stadium, Glendale, AZ
- Spread: Seahawks -4.5, Cardinals +4.5
- Moneyline: Seahawks -225, Cardinals +185
- O/U: 40.5
Super Bowl LX champions Seattle opened the 2026 regular season with a 13-10 win against the Eagles, and are on the road against Arizona in Week 2. The Cardinals also won in Week 1, defeating the Chargers 26-14. See the latest Sam Darnold odds and Jacoby Brissett odds ahead of the game.
Washington Commanders @ Dallas Cowboys Odds, Spread, and Betting Lines
Date/Time: Sept. 20, 2026 | 4:25 p.m. ET
Location: AT&T Stadium, Arlington, TX
- Spread: Commanders +3.5, Cowboys -3.5
- Moneyline: Commanders +160, Cowboys -195
- O/U: 50.5
Washington travels to Texas to play the Cowboys in Week 2. Both of these teams opened the regular season with a loss - the Commanders were defeated 24-22 by the Eagles, and Dallas lost 28-20 vs. the Giants. See the latest Jayden Daniels odds and Dak Prescott odds ahead of the game.
Indianapolis Colts @ Kansas City Chiefs Odds, Spread, and Betting Lines
Date/Time: Sept. 20, 2026 | 8:20 p.m. ET
Location: Arrowhead Stadium, Kansas City, MO
- Spread: Colts +6.5, Chiefs -6.5
- Moneyline: Colts +240, Chiefs -300
- O/U: 48
Indianapolis is on the road against Kansas City in Week 2. The Colts opened the regular season with a 41-23 defeat against the Baltimore Ravens, and are outsiders against the Chiefs at +6.5 on the spread. See the latest Patrick Mahomes odds and Daniel Jones odds ahead of the game.
New York Giants @ Los Angeles Rams Odds, Spread, and Betting Lines
Date/Time: Sept. 21, 2026 | 8:15 p.m. ET
Location: SoFi Stadium, Inglewood, CA
- Spread: Giants +7, Rams -7
- Moneyline: Giants +290, Rams -375
- O/U: 48.5
Preseason Super Bowl LXI favorites the Los Angeles Rams opened the regular season with a disappointing 27-7 defeat vs. the 49ers. The Giants won in Week 1, defeating the Cowboys 28-20 at the MetLife Stadium. See the latest Jaxson Dart odds and Matthew Stafford odds ahead of the game.