49ers vs. Cowboys Odds, Spreads, and Lines
The San Francisco 49ers and Dallas Cowboys will go to head-to-head in this NFL Week 10 game on Sunday afternoon. The game will kick-off at 4:25 p.m. ET, and will be played at AT&T Stadium.
Below, you'll find the latest 49ers vs. Cowboys odds, spreads and betting lines at Fanatics Sportsbook, along with betting trends and additional game information. There's a wide range of NFL betting guidance, odds, and more at Fanatics Sportsbook.
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49ers vs. Cowboys Matchup Information
Date: Sunday, Nov. 15, 2026
Time: 4:05 p.m. ET
Location: AT&T Stadium, Arlington, TX
TV: FOX
49ers vs. Cowboys Odds
The 49ers are -215 moneyline favorites against Dallas, with the Cowboys listed as +175 underdogs. Fanatics Sportsbook is offering point spread markets, totals lines, and prop markets for the game.
You can also check out our guides on how to bet on the NFL and how to bet on the Super Bowl. For more betting tips and strategy, explore our moneyline betting guide, online betting guide, and how to use FanCash.
49ers vs. Cowboys Moneyline Odds
- 49ers Moneyline -215
- Cowboys Moneyline +175
The above odds are correct at the time of writing, see below for live odds
49ers vs. Cowboys Spread Odds
- 49ers -4 -110
- Cowboys +4 -110
- 49ers -8.5 +175
- Cowboys +8.5 -225
- 49ers +1.5 -250
- Cowboys -1.5 +190
49ers vs. Cowboys Over/Under Odds
- Over 55.5 -110
- Under 55.5 -110
- Over 60.5 +175
- Under 60.5 -225
- Over 50.5 -190
- Under 50.5 +150
49ers vs. Cowboys Player Prop Odds
Christain McCaffrey is the most likely scorer in the anytime touchdown market at Fanatics Sportsbook, at odds of -340. Javonte Williams and CeeDee Lamb are next on the board. See the latest Brock Purdy odds and Dak Prescott odds ahead of kickoff.
Fanatics Sportsbook is offering a range of additional player prop markets for the 49ers vs. Cowboys game, including passing touchdowns, receiving yards, rushing yards, receptions, and more.
49ers vs. Cowboys Anytime Touchdown Scorer Odds
- Christian McCaffrey -340
- Javonte Willians -205
- CeeDee Lamb -130
- George Kittle -125
- Brock Purdy +125
49ers vs. Cowboys +EV Bets
Below are the highest positive expected value bets for the 49ers vs. Cowboys game at Fanatics Sportsbook:
- San Francisco 49ers -4.5 Spread +100 (EV 11.78%)
- San Francisco 49ers -5.5 Spread +110 (EV 11.2%)
- San Francisco 49ers -3.5 Spread -115 (EV 9.93%)
49ers vs. Cowboys Odds FAQs
What are the latest odds for 49ers vs. Cowboys?
The 49ers are -215 moneyline favorites at Fanatics Sportsbook, with the Cowboys available at +175. The point spread line is set at 4, with the over/under total line at 55.5 at Fanatics Sportsbook.
Who is favored to win 49ers vs. Cowboys?
The 49ers are available at -215 on the moneyline, which is a 68.25% win probability.
What is the point spread for 49ers vs. Cowboys?
The point spread for the 49ers vs. Cowboys is 4 at Fanatics Sportsbook, with Seattle at -4 and Las Vegas at +4.
What is the over/under for 49ers vs. Cowboys?
The over/under line for the 49ers vs. Cowboys at Fanatics Sportsbook is 55.5.
Where can I find the latest 49ers vs. Cowboys betting lines?
You can find the latest betting lines for 49ers vs. Cowboys at Fanatics Sportsbook. Fanatics offers moneyline, spread, and totals markets, as well as team and player prop betting options for every NFL game in 2026.