76ers vs. Pistons Odds, Spread, Line & Betting Preview
The Philadelphia 76ers and Detroit Pistons will go to head-to-head in this 2026-27 NBA game on Wednesday night. The game will tip-off at 7:00 p.m. ET, and will be played at Little Caesars Arena.
Below, you'll find the latest 76ers vs. Pistons odds, spreads and betting lines at Fanatics Sportsbook, along with betting trends and additional game information. There's a wide range of NBA betting guidance, odds, and more at Fanatics Sportsbook.
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76ers vs. Pistons Matchup Information
Date: Wednesday, Nov. 4, 2026
Time: 7:00 p.m. ET
Location: Little Caesars Arena
TV: NBC/Peacock
76ers vs. Pistons Odds
Detroit is the -130 moneyline favorite against the 76ers at Fanatics Sportsbook, with Philadelphia +110 moneyline outsiders. Fanatics Sportsbook is offering point spread markets, totals lines, and prop markets for the game.
76ers vs. Pistons Moneyline Odds
- 76ers Moneyline +110
- Pistons Moneyline -130
The above odds are correct at the time of writing, see below for live odds
76ers vs. Pistons Spread Odds
- Pistons -2 -115
- 76ers +2 -105
- Pistons -10.5 +290
- 76ers +10.5 -400
- Pistons +6.5 -300
- 76ers -6.5 +230
76ers vs. Pistons Total Points Odds
- Over 218 -110
- Under 218 -110
- Over 228.5 +220
- Under 228.5 -275
- Over 208.5 -270
- Under 208.5 +210
76ers vs. Pistons Player Prop Odds
Fanatics Sportsbook is offering a range of additional player prop markets for the 76ers vs. Pistons game, including points, rebounds, assists, three-pointers made, PRA totals (points, rebounds, and assists combined), and more.
76ers vs. Pistons Player Points Odds
- Joel Embiid Over 18.5 Points -125
- John Collins Over 11.5 Points -125
- Afernee Simons Over 9.5 Points +130
- Cade Cunningham Over 24.5 Points +100
- LeBron James Over 14.5 Points -115
76ers vs. Pistons +EV Bets
Below are the highest positive expected value bets for the 76ers vs. Pistons game at Fanatics Sportsbook:
- LeBron James Over 14.5 Points -115 (EV 44.84%)
- Tyrese Maxey Over 23.5 Points -105 (EV 37.82%)
- Cade Cunningham Over 5.5 Rebounds +105 (EV 36.59%)
76ers vs. Pistons Odds FAQs
What are the latest odds for 76ers vs. Pistons?
The Pistons are moneyline favorites at -130, the 76ers are moneyline outsiders at +110. The point spread line is set at 2, with the over/under total line at 218 at Fanatics Sportsbook.
Who is favored to win 76ers vs. Pistons?
The Pistons are favored to win against the 76ers with moneyline odds of -130, which implies a 56.5% win probability.
What is the point spread for 76ers vs. Pistons?
The point spread for the 76ers vs. Pistons is 2 at Fanatics Sportsbook, with Detroit at -2 and Philadelphia at +2.
What is the over/under for 76ers vs. Pistons?
The over/under line for the 76ers vs. Pistons at Fanatics Sportsbook is 218.
Where can I find the latest 76ers vs. Pistonsbetting lines?
You can find the latest betting lines for 76ers vs. Pistons at Fanatics Sportsbook. Fanatics offers moneyline, spread, and totals markets, as well as team and player prop betting options for every NFL game in 2026.