Broncos vs. 49ers Odds, Spreads, and Lines
The Denver Broncos and San Francisco 49ers will go to head-to-head in this NFL Week 4 game on Sunday afternoon. The game will kick-off at 4:25 p.m. ET, and will be played at Levi's Stadium.
Below, you'll find the latest Broncos vs. 49ers odds, spreads and betting lines at Fanatics Sportsbook, along with betting trends and additional game information. There's a wide range of NFL betting guidance, odds, and more at Fanatics Sportsbook.
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Broncos vs. 49ers Matchup Information
Date: Sunday, Oct. 4, 2026
Time: 4:25 p.m. ET
Location: Levi's Stadium, Santa Clara, CA
TV: CBS
Broncos vs. 49ers Odds
San Francisco is the -145 moneyline favorite against the Broncos at Fanatics Sportsbook, with Denver +120 moneyline outsiders. Fanatics Sportsbook is offering point spread markets, totals lines, and prop markets for the game.
Broncos vs. 49ers Moneyline Odds
- 49ers Moneyline -145
- Broncos Moneyline +120
The above odds are correct at the time of writing, see below for live odds
Broncos vs. 49ers Spread Odds
- Broncos +2.5 -105
- 49ers -2.5 -115
- Broncos +7.5 -285
- 49ers -7.5 +215
- Broncos -1.5 +135
- 49ers +1.5 -170
Broncos vs. 49ers Over/Under Odds
- Over 48.5 -110
- Under 48.5 -110
- Over 44 -180
- Under 44 +145
- Over 53 +165
- Under 53 -210
Broncos vs. 49ers Player Prop Odds
Christian McCaffrey is the most likely scorer in the anytime touchdown market at Fanatics Sportsbook, at odds of -185. J.K. Dobbins and Deebo Samuel are next on the board. See the latest Brock Purdy odds and Bo Nix odds ahead of kickoff.
Fanatics Sportsbook is offering a range of additional player prop markets for the Broncos vs. 49ers game, including passing touchdowns, receiving yards, rushing yards, receptions, and more.
Broncos vs. 49ers Anytime Touchdown Scorer Odds
- Christian McCaffrey -185
- J.K. Dobbins +115
- Deebo Samuel +150
- George Kittle +155
- Mike Evans +170
- RJ Harvey +210
Broncos vs. 49ers +EV Bets
Below are the highest positive expected value bets for the Broncos vs. 49ers game at Fanatics Sportsbook:
- Kaelon Black Over 25.5 Rushing Yards (EV 13.61%)
- J.K. Dobbins Under 60.5 Rushing Yards (EV 13.35%)
- Mike Evans Anytime Touchdown Scorer (EV 13.27%)
- George Kittle Anytime Touchdown Scorer (EV 12.07%)
- J.K. Dobbins Under 65.5 Rushing Yards (EV 10.45%)
Broncos vs. 49ers Odds FAQs
What are the latest odds for Broncos vs. 49ers?
The 49ers are moneyline favorites at -145, the Broncos are moneyline outsiders at +120. The point spread line is set at 2.5, with the over/under total line at 48.5 at Fanatics Sportsbook.
Who is favored to win Broncos vs. 49ers?
The 49ers are favored to win against the Broncos with moneyline odds of -145, which implies a 59.18% win probability.
What is the point spread for Broncos vs. 49ers?
The point spread for the Broncos vs. 49ers is 2.5 at Fanatics Sportsbook, with Denver at +2.5 and San Francisco at -2.5.
What is the over/under for Broncos vs. 49ers?
The over/under line for the Broncos vs. 49ers at Fanatics Sportsbook is 48.5.
Where can I find the latest Broncos vs. 49ers betting lines?
You can find the latest betting lines for Broncos vs. 49ers at Fanatics Sportsbook. Fanatics offers moneyline, spread, and totals markets, as well as team and player prop betting options for every NFL game in 2026.