Cardinals vs. 49ers Odds, Spreads, and Lines
The Arizona Cardinals and San Francisco 49ers will go to head-to-head in this NFL Week 3 game on Sunday afternoon. The game will kick-off at 4:05 p.m. ET, and will be played at Levi's Stadium.
Below, you'll find the latest Cardinals vs. 49ers odds, spreads and betting lines at Fanatics Sportsbook, along with betting trends and additional game information. There's a wide range of NFL betting guidance, odds, and more at Fanatics Sportsbook.
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Cardinals vs. 49ers Matchup Information
Date: Sunday, Sept. 27, 2026
Time: 4:05 p.m. ET
Location: Levi's Stadium, Santa Clara, CA
TV: FOX
Cardinals vs. 49ers Odds
San Francisco is the -400 moneyline favorite against the Cardinals at Fanatics Sportsbook, with Arizona +310 moneyline outsiders. Fanatics Sportsbook is offering point spread markets, totals lines, and prop markets for the game.
Cardinals vs. 49ers Moneyline Odds
- 49ers Moneyline -400
- Cardinals Moneyline +310
The above odds are correct at the time of writing, see below for live odds
Cardinals vs. 49ers Spread Odds
- Cardinals +8.5 -110
- 49ers -8.5 -110
- Cardinals +13.5 -195
- 49ers -13.5 +155
- Cardinals +3.5 +185
- 49ers -3.5 -240
Cardinals vs. 49ers Over/Under Odds
- Over 48 -110
- Under 48 -110
- Over 43.5 -190
- Under 43.5 +150
- Over 52.5 +150
- Under 52.5 -190
Cardinals vs. 49ers Player Prop Odds
Christian McCaffrey is the most likely scorer in the anytime touchdown market at Fanatics Sportsbook, at odds of -225. Jeremiyah Love and Tyler Allgeier are next on the board. See the latest Jacoby Brissett odds and Brock Purdy odds ahead of kickoff.
Fanatics Sportsbook is offering a range of additional player prop markets for the Cardinals vs. 49ers, including passing touchdowns, receiving yards, rushing yards, receptions, and more.
Cardinals vs. 49ers Anytime Touchdown Scorer Odds
- Christian McCaffrey -225
- Jeremiyah Love +125
- Tyler Allgeier +155
- Mike Evans +160
- George Kittle +190
- Deebo Samuel +215
Cardinals vs. 49ers +EV Bets
Below are the highest positive expected value bets for the Cardinals vs. 49ers game at Fanatics Sportsbook:
- Arizona Cardinals Moneyline (EV 27.1%)
- Arizona Cardinals +7 Points (EV 15.63%)
- Arizona Cardinals +9.5 Points (EV 9.96%)
Cardinals vs. 49ers Odds FAQs
What are the latest odds for Cardinals vs. 49ers?
The 49ers are moneyline favorites at -400, the Cardinals are moneyline outsiders at +310. The point spread line is set at 8.5, with the over/under total line at 48 at Fanatics Sportsbook.
Who is favored to win Cardinals vs. 49ers?
The 49ers are favored to win against the Cardinals with moneyline odds of -400, which implies a 80% win probability.
What is the point spread for Cardinals vs. 49ers?
The point spread for the Cardinals vs. 49ers is 8.5 at Fanatics Sportsbook, with San Francisco at +8.5 and Arizona at -8.5.
What is the over/under for Cardinals vs. 49ers?
The over/under line for the Cardinals vs. 49ers at Fanatics Sportsbook is 48.
Where can I find the latest Cardinals vs. 49ers betting lines?
You can find the latest betting lines for Cardinals vs. 49ers at Fanatics Sportsbook. Fanatics offers moneyline, spread, and totals markets, as well as team and player prop betting options for every NFL game in 2026.