Chargers vs. Bills Odds, Spreads, and Lines
The Los Angeles Chargers and Buffalo Bills will go to head-to-head in this NFL Week 3 game on Sunday afternoon. The game will kick-off at 1:00 p.m. ET, and will be played at the Highmark Stadium.
Below, you'll find the latest Chargers vs. Bills odds, spreads and betting lines at Fanatics Sportsbook, along with betting trends and additional game information. There's a wide range of NFL betting guidance, odds, and more at Fanatics Sportsbook.
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Chargers vs. Bills Matchup Information
Date: Sunday, Sept. 27, 2026
Time: 1:00 p.m. ET
Location: Highmark Stadium, Buffalo, NY
TV: FOX
Chargers vs. Bills Odds
Buffalo is the -350 moneyline favorite against the Chargers at Fanatics Sportsbook, with Los Angeles +275 moneyline outsiders. Fanatics Sportsbook is offering point spread markets, totals lines, and prop markets for the game.
Chargers vs. Bills Moneyline Odds
- Bills Moneyline -350
- Chargers Moneyline +275
The above odds are correct at the time of writing, see below for live odds
Chargers vs. Bills Spread Odds
- Chargers +7 -110
- Bills -7 -110
- Chargers +11.5 -195
- Bills -11.5 +155
- Chargers +2.5 +210
- Bills -2.5 -280
Chargers vs. Bills Over/Under Odds
- Over 50 -110
- Under 50 -110
- Over 45.5 -190
- Under 45.5 +150
- Over 54.5 +150
- Under 54.5 -190
Chargers vs. Bills Player Prop Odds
James Cook is the most likely scorer in the anytime touchdown market at Fanatics Sportsbook, at odds of -185 Josh Allen and Omarion Hampton are next on the board. See the latest Josh Allen odds and Justin Herbert odds ahead of kickoff.
Fanatics Sportsbook is offering a range of additional player prop markets for the Chargers vs. Bills, including passing touchdowns, receiving yards, rushing yards, receptions, and more.
Chargers vs. Bills Anytime Touchdown Scorer Odds
- James Cook -185
- Josh Allen -150
- Omarion Hampton -125
- D.J. Moore +165
- Khalil Shakir +200
- Dalton Kincaid +215
Chargers vs. Bills +EV Bets
Below are the highest positive expected value bets for the Chargers vs. Bills game at Fanatics Sportsbook:
- Dalton Kincaid Anytime Touchdown Scorer (EV 26.09%)
- Ladd McConkey Anytime Touchdown Scorer (EV 20.02%)
- Josh Allen Over 240.5 Passing Yards (EV 16.62%)
Chargers vs. Bills Odds FAQs
What are the latest odds for Chargers vs. Bills?
The Bills are moneyline favorites at -350, the Chargers are moneyline outsiders at +275. The point spread line is set at 7, with the over/under total line at 50 at Fanatics Sportsbook.
Who is favored to win Chargers vs. Bills?
The Bills are favored to win against the Chargers with moneyline odds of -350, which implies a 77.78% win probability.
What is the point spread for Chargers vs. Bills?
The point spread for the Chargers vs. Bills is 7 at Fanatics Sportsbook, with Los Angeles at +7 and Buffalo at -7.
What is the over/under for Chargers vs. Bills?
The over/under line for the Chargers vs. Bills at Fanatics Sportsbook is 50.
Where can I find the latest Chargers vs. Bills betting lines?
You can find the latest betting lines for Chargers vs. Bills at Fanatics Sportsbook. Fanatics offers moneyline, spread, and totals markets, as well as team and player prop betting options for every NFL game in 2026.