Giants vs. Rams Odds, Spreads, and Lines
The New York Giants and Los Angeles Rams go to head-to-head in this NFL Week 2 game on Monday night. The game will kick-off at 8:15 p.m. ET, and will be played at the SoFi Stadium in Inglewood.
Below, you'll find the latest Giants vs. Rams odds, spreads and betting lines at Fanatics Sportsbook, along with betting trends and additional game information. There's a wide range of NFL betting guidance, odds, and more at Fanatics Sportsbook.
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Giants vs. Rams Matchup Information
Date: Monday, Sept. 21, 2026
Time: 8:15 p.m. ET
Location: SoFi Stadium, Inglewood, CA
TV: ABC/ESPN
Giants vs. Rams Odds
Los Angeles is the -340 moneyline favorite against the Giants at Fanatics Sportsbook, with New York +265 moneyline outsiders. Fanatics Sportsbook is offering point spread markets, totals lines, and prop markets for the Week 2 game.
Giants vs. Rams Moneyline Odds
- Giants Moneyline +265
- Rams Moneyline -340
The above odds are correct at the time of writing, see below for live odds
Giants vs. Rams Spread Odds
- Giants +7 -105
- Rams -7 -115
- Giants +11.5 -205
- Rams -11.5 +160
- Giants +2.5 +200
- Rams -2.5 -265
Giants vs. Rams Over/Under Odds
- Over 48 -110
- Under 48 -110
- Over 43.5 -190
- Under 43.5 +150
- Over 51.5 +130
- Under 51.5 -160
Giants vs. Rams Player Prop Odds
Kyren Williams is the most likely scorer in the anytime touchdown market at Fanatics Sportsbook, at odds of -125. Puka Nacua and Davante Adams are next on the board. See the latest Matthew Stafford odds and Jaxson Dart odds ahead of kickoff.
Fanatics Sportsbook is offering a range of additional player prop markets for Giants vs. Rams, including passing touchdowns, receiving yards, rushing yards, receptions, and more.
Giants vs. Rams Anytime Touchdown Scorer Odds
- Kyren Williams -125
- Puka Nacua +100
- Davante Adams +120
- Cameron Skattebo +125
- Blake Corum +165
- Malik Nabers +200
Giants vs. Rams Betting Trends
Below are live betting odds from Fanatics Sportsbook, as well as hit rate data and trends across recent games:
- Matthew Stafford has exceeded 240.5 passing yards in 9 of their last 10 games.
- Matthew Stafford has exceeded 255.5 passing yards in 8 of their last 10 games.
- Malik Nabers has exceeded 60.5 receiving yards in 8 of their last 10 games.
Giants vs. Rams FAQs
What are the latest odds for Giants vs. Rams?
The Rams are moneyline favorites at -340, the Giants are moneyline outsiders at +265. The point spread line is set at 7, with the over/under total line at 48 at Fanatics Sportsbook.
Who is favored to win Giants vs. Rams?
The Rams are favored to win against the Giants with moneyline odds of -340, which implies a 77.3% win probability.
What is the point spread for Giants vs. Rams?
The point spread for the Giants vs. Rams is 7 at Fanatics Sportsbook, with New York at +7 and Los Angeles at -7.
What is the over/under for Giants vs. Rams?
The over/under line for Giants vs. Rams at Fanatics Sportsbook is 48.
Where can I find the latest Giants vs. Rams betting lines?
You can find the latest betting lines for Giants vs. Rams at Fanatics Sportsbook. Fanatics offers moneyline, spread, and totals markets, as well as team and player prop betting options for every NFL game in 2026.