NFL Preseason Week 1 Odds, Spreads, and Lines
NFL preseason football returns this week as all 32 teams take the field for the first full slate of exhibition action ahead of the 2026 regular season. Preseason games give bettors a chance to evaluate roster depth, quarterback battles, and emerging talent across the league.
Below, you'll find the latest NFL preseason Week 1 odds, spreads and betting lines at Fanatics Sportsbook, along with matchup information for every game on the schedule. There's a wide range of NFL betting guidance, odds, and more at Fanatics Sportsbook.
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NFL Week 1 Preseason Odds
Detroit Lions @ Cincinnati Bengals Odds, Spread, and Betting Lines
Date/Time: Aug. 13, 2026 | 7:00 p.m. ET
Location: Paycor Stadium in Cincinnati, OH
- Spread: Bengals -6.5, Lions +6.5
- Moneyline: Bengals -280, Lions +225
- O/U: 38.5
The Bengals and Lions kick off their 2026 preseason schedules at Paycor Stadium on Thursday night, in a matchup between two legitimate playoff contenders.
Cincinnati has one of the most talented rosters in the AFC and are looking to respond after a difficult 2025 campaign. Detroit is viewed as one of the strongest teams in the NFC and this is a good opportunity to assess their emerging talent.
Green Bay Packers @ Pittsburgh Steelers Odds, Spread, and Betting Lines
Date/Time: Aug. 13, 2026 | 7:00 p.m. ET
Location: Acrisure Stadium in Pittsburgh, PA
- Spread: Packers -1.5, Steelers +1.5
- Moneyline: Packers -130, Steelers +110
- O/U: 39.5
The Packers and Steelers meet in their opening preseason games of 2026 on Thursday night. Both Green Bay and Pittsburgh are expected to give plenty of playing time to rookies and backup players, giving fans a first look at several offseason additions.
Both teams have high expectations for the 2026 season, having each lost in the Wild Card Round in 2025, to the Bears and Texans, respectively.
Indianapolis Colts @ New England Patriots Odds, Spread, and Betting Lines
Date/Time: Aug. 13, 2026 | 7:30 p.m. ET
Location: Gillette Stadium in Foxborough, MA
- Spread: Colts -2.5, Patriots +2.5
- Moneyline: Colts -150, Patriots +125
- O/U: 38.5
The Colts and Patriots kick off their 2026 preseason schedules on Thursday night in Foxborough. This is a good opportunity for the Colts to assess their roster depth against a New England team that appeared at Super Bowl LX.
The Patriots will be chasing a championship again this season after an impressive 2025, while Indianapolis will be aiming to make the playoffs for the first time since 2020.
Los Angeles Chargers @ Houston Texans Odds, Spread, and Betting Lines
Date/Time: Aug. 13, 2026 | 8:00 p.m. ET
Location: NRG Stadium in Houston, TX
- Spread: Texans -0.5, Chargers +0.5
- Moneyline: Texans -125, Chargers +105
- O/U: 38
The Chargers travel to Houston to face the Texans in their first preseason game. Both teams have playoff ambitions for 2026, with each expected to assess their rookies and backups in this game.
The Chargers have gone 11-6 in consecutive seasons, losing in the Wild Card Round to Houston in 2024. The Texans managed 12 wins last campaign, but were defeated by Super Bowl runners-up New England in the Divisional Round.
Arizona Cardinals @ Las Vegas Raiders Odds, Spread, and Betting Lines
Date/Time: Aug. 13, 2026 | 8:00 p.m. ET
Location: Allegiant Stadium in Las Vegas Valley, NV
- Spread: Raiders -0.5, Cardinals +0.5
- Moneyline: Raiders -130, Cardinals +110
- O/U: 42
The Raiders and Cardinals meet in this 2026 preseason game on Thursday night. It is set to be a rebuilding campaign for Arizona, urrently tied for the lowest projected win total in the NFL. This game will be about assessing their backup players.
The Raiders enter preseason under new head coach Klint Kubiak. This game should offer an early look at Kubiak's system and coaching philosophy. Las Vegas could also get to see their new quarterback, Fernando Mendoza for the first time.
Tennessee Titans @ San Francisco 49ers Odds, Spread, and Betting Lines
Date/Time: Aug. 13, 2026 | 9:00 p.m. ET
Location: Levi's Stadium in Santa Clara, CA
- Spread: Titans -5, 49ers +5
- Moneyline: Titans -225, 49ers +185
- O/U: 40
The 49ers and Titans kick off their preseason schedules in Santa Clara on Thursday night. San Francisco are likely to use this game to assess their roster depth ahead of the start of the season, as the 49ers chase a first NFC West title since 2023.
Tennessee has had consecutive difficult seasons, posting 3-14 records in 2024 and 2025. This will be an opportunity for the Titans to assess their young talent and offseason additions.
Miami Dolphins @ Washington Commanders Odds, Spread, and Betting Lines
Date/Time: Aug. 14, 2026 | 7:00 p.m. ET
Location: Northwest Stadium in Summerfield, MD
- Spread: Dolphins -3, Commanders +3
- Moneyline: Dolphins -150, Commanders +125
- O/U: 36.5
The Dolphins travel to face the Commanders in this preseason game. Miami are set for a season of rebuilding in the AFC East and this is a good opportunity for the coaching staff to assess their backup quarterbacks and young receivers.
Washington have outside playoff hopes for 2026, but will need to improve on their 5-12 record from 2025. The Commanders have added talent to their roster over recent seasons and reached the NFC Championship Game in 2024.
Denver Broncos @ Atlanta Falcons Odds, Spread, and Betting Lines
Date/Time: Aug. 14, 2026 | 7:00 p.m. ET
Location: Pisa Mercedes-Benz in Atlanta, GA
- Spread: Broncos -5.5, Falcons +5.5
- Moneyline: Broncos -245, Falcons +200
- O/U: 38.5
The Falcons host the Broncos in this preseason game on Friday night. Atlanta possesses one of the league's most talented young rosters, and several rookies and backups are expected to feature against Denver.
The Broncos have posted a 9.5 win total for 2026 and have legitimate playoff expectations. Denver reached 14 wins in 2025 and missed the Super Bowl after being defeated by New England in the AFC Championship Game.
Tampa Bay Buccaneers @ New York Jets Odds, Spread, and Betting Lines
Date/Time: Aug. 14, 2026 | 7:00 p.m. ET
Location: MetLife Stadium in East Rutherford, NJ
- Spread: Jets -6, Buccaneers +6
- Moneyline: Jets -260, Buccaneers +210
- O/U: 35.5
The Buccaneers travel to face the Jets in this preseason game. Both teams have playoff ambitions for 2026, and this will be a good test for both to assess their roster depth. The Buccaneers have had strong roster depth in recent seasons, and will be looking at younger players in this game to retain that strength for 2026.
The Jets have several position battles worth monitoring, including their backup quarterback and wide receiver. New York has failed to make the playoffs since 2010, and pressure is building for the Jets to snap that unwanted streak in 2026.
Cleveland Browns @ Chicago Bears Odds, Spread, and Betting Lines
Date/Time: Aug. 15, 2026 | 1:00 p.m. ET
Location: Soldier Field in Chicago, IL
- Spread: Browns -0.5, Bears +0.5
- Moneyline: Browns -125, Bears +105
- O/U: 40
The Bears host the Browns on Saturday afternoon in this preseason game. Chicago has invested heavily in developing its roster in recent seasons, and this game will provide the coaching staff with insight ahead of final roster cuts.
Cleveland will also be looking to assess its depth at quarterback, as well as young playmakers and defensive reserves. The Browns are looking to avoid a 4th place finish in the AFC North for the first time since 2023.
Carolina Panthers @ Buffalo Bills Odds, Spread, and Betting Lines
Date/Time: Aug. 15, 2026 | 1:00 p.m. ET
Location: Highmark Stadium in Orchard Park, NY
- Spread: Bills -0.5, Panthers +0.5
- Moneyline: Bills -120, Panthers +100
- O/U: 37.5
The Panthers kick off their 2026 preseason schedule against the Bills on Saturday afternoon. Carolina has playoff ambitions for 2026, having appeared in the postseason for the first time since 2017 last campaign. This game will give the Panthers coaching staff an opportunity to evaluate young players on both sides of the ball.
The Bills are tipped as serious Super Bowl LXI contenders in 2026, currently joint-second on the board to win the championship, behind the Los Angeles Rams. Buffalo are looking to build a strong roster in preparation for a potential long playoff run.
Minnesota Vikings @ New York Giants Odds, Spread, and Betting Lines
Date/Time: Aug. 15, 2026 | 1:00 p.m. ET
Location: MetLife Stadium in East Rutherford, NJ
- Spread: Vikings -1, Giants +1
- Moneyline: Vikings -130, Giants +110
- O/U: 41
The Vikings travel to face the Giants in this preseason game in New Jersey. Minnesota is expected to give opportunities to offensive backups and reserve linemen, to help evaluate their roster depth ahead of the season. The Vikings have playoff aspirations for 2026.
The Giants will also be taking a close look at their young talent. New York are looking to improve on consecutive NFC East 4th place finishes in recent seasons.
Los Angeles Rams @ Kansas City Chiefs Odds, Spread, and Betting Lines
Date/Time: Aug. 15, 2026 | 4:00 p.m. ET
Location: Arrowhead Stadium in Kansas City, MO
- Spread: Chiefs -2.5, Rams +2.5
- Moneyline: Chiefs -140, Rams +115
- O/U: 36.5
The Rams travel to face the Chiefs in this preseason clash on Saturday afternoon. Los Angeles are strong on the board to win Super Bowl LXI, and this is a good opportunity to continue evaluating their depth chart and young talent.
The Chiefs will be looking to put a disappointing 2025 season behind them, and this presents an opportunity for them to make an early statement against one of the Super Bowl favorites.
Jacksonville Jaguars @ New Orleans Saints Odds, Spread, and Betting Lines
Date/Time: Aug. 15, 2026 | 4:00 p.m. ET
Location: Caesars Superdome in New Orleans, LA
- Spread: Saints -3, Jaguars +3
- Moneyline: Saints -107, Jaguars +140
- O/U: 36.5
The Saints host the Jaguars on Saturday afternoon in this 2026 preseason game. With roster decisions still to be made by both teams, expect backups and rookies to be given plenty of snaps in this clash.
The Saints have had consecutive disappointing seasons and improving their roster depth could be vital in their attempt to make the postseason for the first time since 2020. Jacksonville impressed in 2025 and will be looking to build on that promise after going 13-4 and reaching the playoffs last season.
Philadelphia Eagles @ Baltimore Ravens Odds, Spread, and Betting Lines
Date/Time: Aug. 15, 2026 | 7:00 p.m. ET
Location: M&T Bank Stadium in Baltimore, MD
- Spread: Eagles -2, Ravens +2
- Moneyline: Eagles -165, Ravens +135
- O/U: 36.5
The Eagles travel to face the Ravens on Saturday night, with both of these teams having championship hopes for 2026. Philadelphia has built a reputation for having strong roster depth in recent seasons, and are expected to give ample opportunity to young players to impress.
Baltimore are another franchise that traditionally boast strong roster depth, which is made necessary due to their often aggressive and physical approach.
Dallas Cowboys @ Seattle Seahawks Odds, Spread, and Betting Lines
Date/Time: Aug. 15, 2026 | 8:00 p.m. ET
Location: Lumen Field in Seattle, WA
- Spread: Seahawks -3.5, Cowboys +3.5
- Moneyline: Seahawks -180, Cowboys +150
- O/U: 39.5
Super Bowl LX champions Seattle host the Cowboys in the final game of this round of preseason matches. Both teams have championship hopes for 2026, and this is a good opportunity for Dallas to assess their depth against the reigning Super Bowl champions.
Seattle have a championship-caliber roster, and this game will provide the coaching staff with the chance to analyze young players who could strengthen their roster depth even further for 2026.