NFL Week 10 Odds, Spreads & Betting Lines for Every NFL Game
The 2026 NFL regular season continues with a full Week 10 slate, with key games including the Commanders @ Giants, Chiefs @ Falcons, Steelers @ Bengals, and Chargers @ Ravens.
Below, you'll find the latest NFL Week 10 odds, spreads and betting lines at Fanatics Sportsbook, along with matchup information for every game on the schedule. There's a wide range of NFL betting guidance, odds, and more at Fanatics Sportsbook.
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NFL Week 10 Odds
Commanders vs. Giants Odds, Spread, and Betting Lines
Date/Time: Nov. 12, 2026 | 8:15 p.m. ET
Location: MetLife Stadium, East Rutherford, NJ
- Spread: Commanders +1.5, Giants -1.5
- Moneyline: Commanders +105, Giants -125
- O/U: 43.5
Washington enters this NFC East matchup looking to stay in the playoff race behind one of the league's most dynamic offenses. The Giants have struggled for consistency on both sides of the ball, but division games are rarely straightforward. Quarterback play and turnovers could prove decisive in a rivalry that often produces close finishes. See the latest Jayden Daniels odds and Jaxson Dart odds ahead of the game.
Patriots vs. Lions Odds, Spread, and Betting Lines
Date/Time: Nov. 15, 2026 | 9:30 a.m. ET
Location: FC Bayern Munich Stadium, Munich, Germany
- Spread: Patriots +2.5, Lions -2.5
- Moneyline: Patriots +130, Lions -155
- O/U: 51
Detroit travels to Germany boasting one of the NFL's most productive offenses after another strong season from Jared Goff and a deep supporting cast. New England continues its rebuild around a young core and improving defense. The Lions are the more complete team, but international games can create unexpected challenges and opportunities. See the latest Drake Maye odds and Jared Goff odds ahead of the game.
Chiefs vs. Falcons Odds, Spread, and Betting Lines
Date/Time: Nov. 15, 2026 | 1:00 p.m. ET
Location: Mercedes-Benz Stadium, Atlanta, GA
- Spread: Chiefs -3, Falcons +3
- Moneyline: Chiefs -180, Falcons +150
- O/U: 45
Kansas City remains a Super Bowl contender behind Patrick Mahomes and Andy Reid, while Atlanta hopes its talented collection of offensive playmakers can challenge the NFC's best teams. The Falcons' defense faces a major test against the Chiefs' creative attack. Limiting explosive plays will be critical if Atlanta hopes to secure an upset. See the latest Patrick Mahomes odds and Tua Tagovailoa odds ahead of the game.
Texans vs. Browns Odds, Spread, and Betting Lines
Date/Time: Nov. 15, 2026 | 1:00 p.m. ET
Location: Huntington Bank Field, Cleveland, OH
- Spread: Texans -4, Browns +4
- Moneyline: Texans -225, Browns +185
- O/U: 39.5
Houston's rise behind C.J. Stroud has transformed the Texans into a consistent playoff threat. Cleveland will lean on a physical defense featuring one of the league's strongest pass rushes. This matchup pits Houston's explosive passing game against a Browns defense capable of disrupting even the NFL's most productive offenses. See the latest Bo Nix odds and Bryce Young odds ahead of the game.
Vikings vs. Packers Odds, Spread, and Betting Lines
Date/Time: Nov. 15, 2026 | 1:00 p.m. ET
Location: Lambeau Field, Green Bay, WI
- Spread: Vikings +3.5, Packers -3.5
- Moneyline: Vikings +145, Packers -175
- O/U: 42
One of the NFL's best rivalries renews at Lambeau Field as Minnesota and Green Bay battle for NFC North positioning. Both teams feature playoff-caliber rosters and explosive offenses. Jordan Love and the Packers will look to protect home field, while the Vikings aim to prove they belong among the conference elite. See the latest Dak Prescott odds and Daniel Jones odds ahead of the game.
Dolphins vs. Colts Odds, Spread, and Betting Lines
Date/Time: Nov. 15, 2026 | 1:00 p.m. ET
Location: Lucas Oil Stadium, Indianapolis, IN
- Spread: Dolphins +2.5, Colts -2.5
- Moneyline: Dolphins +115, Colts -140
- O/U: 40.5
Miami's speed-heavy offense presents a difficult challenge for any defense, particularly with Tyreek Hill capable of changing games in a single play. Indianapolis continues to build around Anthony Richardson and an improving young roster. Success in the trenches and limiting explosive plays could determine which team leaves with a valuable win. See the latest Malik Willis odds and Daniel Jones odds ahead of the game.
Bills vs. Jets Odds, Spread, and Betting Lines
Date/Time: Nov. 15, 2026 | 1:00 p.m. ET
Location: MetLife Stadium, East Rutherford, NJ
- Spread: Bills -7.5, Jets +7.5
- Moneyline: Bills -450, Jets +340
- O/U: 51
Buffalo visits New York in a rivalry that has grown increasingly important in the AFC East. Josh Allen remains one of football's most dangerous dual-threat quarterbacks, while the Jets boast a defense capable of competing with anybody. If New York can pressure Allen consistently, this contest could remain tight throughout. See the latest Josh Allen odds and Geno Smith odds ahead of the game.
Panthers vs. Saints Odds, Spread, and Betting Lines
Date/Time: Nov. 15, 2026 | 1:00 p.m. ET
Location: Caesers Superdrome, New Orleans, LA
- Spread: Panthers +1, Saints -1
- Moneyline: Panthers -110, Saints -110
- O/U: 47.5
Carolina and New Orleans meet in an important NFC South clash between division rivals looking to gain ground in a competitive race. The Panthers continue developing a young roster, while the Saints rely on experienced veterans and defensive strength. Field position, turnovers, and red-zone efficiency could ultimately decide this matchup. See the latest Bryce Young odds and Tyler Shough odds ahead of the game.
Jaguars vs. Titans Odds, Spread, and Betting Lines
Date/Time: Nov. 15, 2026 | 1:00 p.m. ET
Location: Northwest Stadium, Landover, MD
- Spread: Jaguars -9, Titans +9
- Moneyline: Jaguars -500, Titans +370
- O/U: 47
Jacksonville and Tennessee renew their AFC South rivalry with division implications on the line. Trevor Lawrence leads a Jaguars offense capable of producing points in bunches, while the Titans aim to control games through physical play. Winning the battle at the line of scrimmage will likely be a major factor here. See the latest Trevor Lawrence odds and Cam Ward odds ahead of the game.
Rams vs. Cardinals Odds, Spread, and Betting Lines
Date/Time: Nov. 15, 2026 | 4:05 p.m. ET
Location: State Farm Stadium, Glendale, AZ
- Spread: Rams -7, Cardinals +7
- Moneyline: Rams -375, Cardinals +290
- O/U: 44.5
An NFC West showdown features two teams hoping to strengthen their playoff credentials. Los Angeles continues to rely on Sean McVay's offensive system and veteran leadership, while Arizona's success hinges on Kyler Murray's playmaking ability. Recent meetings have often been competitive, making this one of the division's more intriguing contests. See the latest Matthew Stafford odds and Jacoby Brissett odds ahead of the game.
49ers vs. Cowboys Odds, Spread, and Betting Lines
Date/Time: Nov. 15, 2026 | 4:25 p.m. ET
Location: AT&T Stadium, Arlington, TX
- Spread: 49ers -4, Cowboys +4
- Moneyline: 49ers -215, Cowboys +175
- O/U: 56
Few regular-season matchups generate more attention than San Francisco versus Dallas. The 49ers have frequently gotten the better of the Cowboys in recent years, thanks to their physical defense and versatile offense. Dallas will look to reverse that trend at home in a game with potential playoff-seeding implications. See the latest Brock Purdy odds and Dak Prescott odds ahead of the game.
Seahawks vs. Raiders Odds, Spread, and Betting Lines
Date/Time: Nov. 15, 2026 | 4:25 p.m. ET
Location: Allegiant Stadium, Paradise, NV
- Spread: Seahawks -3.5, Raiders +3.5
- Moneyline: Seahawks -195, Raiders +160
- O/U: 43.5
Seattle brings an experienced roster into Las Vegas for an intriguing interconference matchup. The Seahawks have traditionally relied on balanced offensive production and opportunistic defense, while the Raiders continue searching for consistency. Home-field advantage could help Las Vegas, but Seattle's experience may prove valuable in key situations late. See the latest Kirk Cousins odds and Sam Darnold odds ahead of the game.
Steelers vs. Bengals Odds, Spread, and Betting Lines
Date/Time: Nov. 15, 2026 | 8:20 p.m. ET
Location: Paycor Stadium, Cincinnati, OH
- Spread: Steelers +3.5, Bengals -3.5
- Moneyline: Steelers +165, Bengals -200
- O/U: 48.5
Pittsburgh and Cincinnati meet in another chapter of one of the AFC North's fiercest rivalries. The Bengals possess an explosive passing attack led by Joe Burrow, while the Steelers traditionally rely on physical defense and strong line play. Recent meetings have been intense, and another closely contested battle should be expected. See the latest Aaron Rodgers odds and Joe Burrow odds ahead of the game.
Chargers vs. Ravens Odds, Spread, and Betting Lines
Date/Time: Nov. 16, 2026 | 8:15 p.m. ET
Location: M&T Bank Stadium, Baltimore, MD
- Spread: Chargers +5, Ravens -5
- Moneyline: Chargers +190, Ravens -235
- O/U: 38.5
Week 10 concludes with a marquee showdown between two AFC contenders. Lamar Jackson leads Baltimore's dynamic offense against a Chargers team built around Justin Herbert's arm talent. Both teams harbor postseason ambitions, and this matchup could have significant tiebreaker implications when the playoff picture begins to take shape. See the latest Justin Herbert odds and Lamar Jackson odds ahead of the game.