NFL Week 4 Odds, Spreads & Betting Lines for Every Game
The 2026 NFL regular season continues with a full Week 4 slate, with key games including the Kansas City Chiefs @ Las Vegas Raiders, Dallas Cowboys @ Houston Texans, and Los Angeles Rams @ Philadelphia Eagles.
Below, you'll find the latest NFL Week 4 odds, spreads and betting lines at Fanatics Sportsbook, along with matchup information for every game on the schedule. There's a wide range of NFL betting guidance, odds, and more at Fanatics Sportsbook.
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NFL Week 4 Odds
Steelers vs. Browns Odds, Spread, and Betting Lines
Date/Time: Oct. 1, 2026 | 8:15 p.m. ET
Location: Huntington Bank Field, Cleveland, OH
- Spread: Steelers -2.5, Browns +2.5
- Moneyline: Steelers -140, Browns +115
- O/U: 38
The Steelers are on the road against Cleveland in Week 4. Pittsburgh defeated the Bengals in Week 3, and has a 2-1 record after three games. The Browns have won back-to-back games against Tampa Bay and Carolina in previous weeks. See the latest Aaron Rodgers odds and Deshaun Watson odds ahead of the game.
Colts vs. Commanders Odds, Spread, and Betting Lines
Date/Time: Oct. 4, 2026 | 9:30 a.m. ET
Location: Tottenham Hotspur Stadium, London, England
- Spread: Colts -3, Commanders +3
- Moneyline: Colts -170, Commanders +140
- O/U: 47
Indianapolis and Washington matchup in this Week 4 game in London. The Colts recorded a first win of the season in Week 3, after losses against Baltimore and Kansas City to start the campaign. Washington also won its first game of the 2026 season last time out, vs. Seattle. See the latest Daniel Jones odds and Jayden Daniels odds ahead of the game.
Cardinals vs. Giants Odds, Spread, and Betting Lines
Date/Time: Oct. 4, 2026 | 1:00 p.m. ET
Location: MetLife Stadium, East Rutherford, NJ
- Spread: Cardinals -0.5, Giants +0.5
- Moneyline: Cardinals -110, Giants -110
- O/U: 44
Arizona travels to New York to play against the Giants in Week 4. The Cardinals opened with a win vs. Los Angeles, but lost their previous two games. The Giants have a 2-1 record after three games, with a win against Tennessee in Week 3. See the latest Jacoby Brissett odds and Jaxson Dart odds ahead of the game.
Cowboys vs. Texans Odds, Spread, and Betting Lines
Date/Time: Oct. 4, 2026 | 1:00 p.m. ET
Location: NRG Stadium, Houston, TX
- Spread: Texans -2.5, Cowboys +2.5
- Moneyline: Texans -140, Cowboys +115
- O/U: 47.5
The Cowboys and the Texans will face off in Houston on Sunday afternoon. Dallas lost to Baltimore in Week 3, after opening with a loss vs. the Giants and a win vs. Washington in Week 2. The Texans have lost all three games so far this season, against Buffalo, Cincinnati, and Indianapolis. See the latest C.J. Stroud odds and Dak Prescott odds ahead of the game.
Packers vs. Buccaneers Odds, Spread, and Betting Lines
Date/Time: Oct. 4, 2026 | 1:00 p.m. ET
Location: Raymond James Stadium, Tampa, FL
- Spread: Packers -3.5, Buccaneers +3.5
- Moneyline: Packers -170, Buccaneers +140
- O/U: 41
Tampa Bay hosts Green Bay in this Week 4 matchup on Sunday afternoon. The Packers opened with a win, both have lost back-to-back games ahead of this outing. The Buccaneers have lost all three games so far this season, against Cincinnati, Cleveland, and Minnesota. See the latest Jordan Love odds and Baker Mayfield odds ahead of the game.
Jaguars vs. Bengals Odds, Spread, and Betting Lines
Date/Time: Oct. 4, 2026 | 1:00 p.m. ET
Location: Paycor Stadium, Cincinnati, OH
- Spread: Bengals -2.5, Jaguars +2.5
- Moneyline: Bengals -140, Jaguars +115
- O/U: 51
The Jaguars are on the road against the Bengals in Week 4. Jacksonville has a 2-1 record after three games, while the Bengals suffered a first loss of the season in Week 3, vs. Pittsburgh. See the latest Trevor Lawrence odds and Joe Burrow odds ahead of the game.
Rams vs. Eagles Odds, Spread, and Betting Lines
Date/Time: Oct. 4, 2026 | 1:00 p.m. ET
Location: Lincoln Financial Field, Philadelphia, PA
- Spread: Rams -2.5, Eagles +2.5
- Moneyline: Rams -140, Eagles +115
- O/U: 46.5
The Rams and the Eagles face off in this Week 4 clash. Preseason Super Bowl favorites Los Angeles has already lost two games heading into Week 4, while Philadelphia has started the season strongly. See the latest Jalen Hurts odds and Matthew Stafford odds ahead of the game.
Patriots vs. Bills Odds, Spread, and Betting Lines
Date/Time: Oct. 4, 2026 | 1:00 p.m. ET
Location: Highmark Stadium, Buffalo, NY
- Spread: Patriots +6.5, Bills -6.5
- Moneyline: Patriots +250, Bills -320
- O/U: 48
The Bills host the Patriots at Highmark Stadium in Week 4. Buffalo has a perfect 3-0 record heading into this matchup, after wins vs. Houston, Detroit, and the Chargers. New England has a 1-2 record after Week 3. See the latest Drake Maye odds and Josh Allen odds ahead of the game.
Jets vs. Bears Odds, Spread, and Betting Lines
Date/Time: Oct. 4, 2026 | 1:00 p.m. ET
Location: Soldier Field, Chicago, IL
- Spread: Bears -3, Jets +3
- Moneyline: Bears -155, Jets +130
- O/U: 43.5
The Jets and the Bears matchup in Chicago for this Week 4 game. New York opened the season with a victory, but posted losses in Week 2 and Week 3. The Bears opened with a win at Carolina, before a loss against the Vikings. See the latest Caleb Williams odds and Geno Smith odds ahead of the game.
Titans vs. Ravens Odds, Spread, and Betting Lines
Date/Time: Oct. 4, 2026 | 1:00 p.m. ET
Location: M&T Bank Stdium, Baltimore, MD
- Spread: Titans +11.5, Ravens -11.5
- Moneyline: Titans +525, Ravens -750
- O/U: 43.5
Tennessee is chasing its first win of the 2026 against Baltimore in Week 4. The Titans have lost against the Jets, the Eagles, and the Giants so far. Baltimore has started the season strongly, with wins vs. Indianapolis and Dallas already. See the latest Cam Ward odds and Lamar Jackson odds ahead of the game.
Dolphins vs. Vikings Odds, Spread, and Betting Lines
Date/Time: Oct. 4, 2026 | 4:05 p.m. ET
Location: U.S. Bank Stadium, Minneapolis, MN
- Spread: Dolphins +10, Vikings -10
- Moneyline: Dolphins +420, Vikings -575
- O/U: 39
Miami will be looking for its first win of the 2026 NFL season against Minnesota on Sunday afternoon. The Dolphins have lost against Las Vegas, San Francisco, and Kansas City so far. The Vikings have started the season with a 3-0 record after Week 3, with wins vs. Green Bay, Chicago, and Tampa Bay. See the latest Malik Willis odds and Kyler Murray odds ahead of the game.
Broncos vs. 49ers Odds, Spread, and Betting Lines
Date/Time: Oct 4. 27, 2026 | 4:25 p.m. ET
Location: Levi's Stadium, Santa Clara, CA
- Spread: 49ers -3, Broncos +3
- Moneyline: 49ers -150, Broncos +125
- O/U: 46.5
The 49ers host Denver in this Week 4 matchup on Sunday afternoon. The Broncos opened with a Week 1 loss, but have won back-to-back games in previous weeks. San Francisco have won all three games so far, vs. the Rams, the Dolphins, and the Cardinals. See the latest Bo Nix odds and Brock Purdy odds ahead of the game.
Chiefs vs. Raiders Odds, Spread, and Betting Lines
Date/Time: Oct. 4, 2026 | 4:25 p.m. ET
Location: Allegiant Stadium, Las Vegas Valley, NV
- Spread: Chiefs -4.5, Raiders +4.5
- Moneyline: Chiefs -220, Raiders +180
- O/U: 47.5
The Chiefs are on the road against Las Vegas in Week 4. Kansas City has started the season strongly, winning all three games so far (vs. Broncos, Colts, and Dolphins). The Raiders have also won all of their games, with victories against Miami, the Chargers, and New Orleans. See the latest Patrick Mahomes odds and Kirk Cousins odds ahead of the game.
Chargers vs. Seahawks Odds, Spread, and Betting Lines
Date/Time: Oct. 4, 2026 | 4:25 p.m. ET
Location: Lumen Field, Seattle, WA
- Spread: Chargers +7, Seahawks -7
- Moneyline: Chargers +250, Seahawks -320
- O/U: 43
The Seahawks and the Chargers matchup in this Week 4 clash on Sunday afternoon. Seattle has a 2-1 record after Week 3, with wins vs. the Patriots and the Cardinals. Los Angeles has lost all three games so far this season, vs. Arizona, Las Vegas, and Buffalo. See the latest Sam Darnold odds and Justin Herbert odds ahead of the game.
Lions vs. Panthers Odds, Spread, and Betting Lines
Date/Time: Oct. 4, 2026 | 8:20 p.m. ET
Location: Bank of America Stadium, Charlotte, NC
- Spread: Lions -3.5, Panthers +3.5
- Moneyline: Lions -170, Panthers +140
- O/U: 50.5
The Lions are on the road vs. Carolina in Week 4. Detroit opened with a win vs. New Orleans, before a loss vs. Buffalo and a win against the Jets in Week 3. Carolina has a 1-2 record heading into Week 4, with their sole win so far coming against the Falcons in Week 2. See the latest Jared Goff odds and Bryce Young odds ahead of the game.
Falcons vs. Saints Odds, Spread, and Betting Lines
Date/Time: Oct. 5, 2026 | 8:15 p.m. ET
Location: Caesers Superdrome, New Orleans, LA
- Spread: Saints -2.5, Falcons +2.5
- Moneyline: Saints -150, Falcons +125
- O/U: 48.5
The Atlanta Falcons and the New Orleans Saints matchup on Monday night at Caesers Superdrome in Louisiana. The Falcons recorded a first win of the 2026 season in Week 3 vs. Green Bay, while the Saints also have a 1-2 record heading into Week 4. See the latest Tyler Shough odds and Tua Tagovailoa odds ahead of the game.