Patriots vs. Bills Odds, Spreads, and Lines
The New England Patriots and Buffalo Bills will go to head-to-head in this NFL Week 4 game on Sunday afternoon. The game will kick-off at 1:00 p.m. ET, and will be played at the Highmark Stadium.
Below, you'll find the latest Patriots vs. Bills odds, spreads and betting lines at Fanatics Sportsbook, along with betting trends and additional game information. There's a wide range of NFL betting guidance, odds, and more at Fanatics Sportsbook.
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Patriots vs. Bills Matchup Information
Date: Sunday, Oct. 4, 2026
Time: 1:00 p.m. ET
Location: Highmark Stadium, Buffalo, NY
TV: ESPN
Patriots vs. Bills Odds
Buffalo is the -320 moneyline favorite against the Patriots at Fanatics Sportsbook, with New England +250 moneyline outsiders. Fanatics Sportsbook is offering point spread markets, totals lines, and prop markets for the game.
Patriots vs. Bills Moneyline Odds
- Patriots Moneyline +250
- Bills Moneyline -320
The above odds are correct at the time of writing, see below for live odds
Patriots vs. Bills Spread Odds
- Patriots +6.5 +100
- Bills -6.5 -120
- Patriots +11.5 -220
- Bills -11.5 +170
- Patriots +2.5 +190
- Bills -2.5 -250
Patriots vs. Bills Over/Under Odds
- Over 49 -110
- Under 49 -110
- Over 44.5 -195
- Under 44.5 +155
- Over 54.5 +160
- Under 54.5 -205
Patriots vs. Bills Player Prop Odds
James Cook is the most likely scorer in the anytime touchdown market at Fanatics Sportsbook, at odds of -155. Josh Allen and Rhamondre Stevenson are next on the board. See the latest Josh Allen odds and Drake Maye odds ahead of kickoff.
Fanatics Sportsbook is offering a range of additional player prop markets for the Patriots vs. Bills game, including passing touchdowns, receiving yards, rushing yards, receptions, and more.
Patriots vs. Bills Anytime Touchdown Scorer Odds
- James Cook -155
- Josh Allen -115
- Rhamondre Stevenson +150
- D.J. Moore +165
- Dalton Kincaid +175
- TreVeyon Henderson +190
Patriots vs. Bills +EV Bets
Below are the highest positive expected value bets for the Patriots vs. Bills game at Fanatics Sportsbook:
- Dalton Kincaid Anytime Touchdown Scorer (EV 15.01%)
- Josh Allen Anytime Touchdown Scorer (EV 12.33%)
- D.J. Moore Anytime Touchdown Scorer (EV 11.67%)
- Romeo Doubs Anytime Touchdown Scorer (EV 7.1%)
- Under 50 Total Points (EV 0.3%)
Patriots vs. Bills Odds FAQs
What are the latest odds for Patriots vs. Bills?
The Bills are moneyline favorites at -320, the Patriots are moneyline outsiders at +250. The point spread line is set at 6.5, with the over/under total line at 49 at Fanatics Sportsbook.
Who is favored to win Patriots vs. Bills?
The Bills are favored to win against the Patriots with moneyline odds of -320, which implies a 76.2% win probability.
What is the point spread for Patriots vs. Bills?
The point spread for the Patriots vs. Bills is 6.5 at Fanatics Sportsbook, with New England at +6.5 and Buffalo at -6.5.
What is the over/under for Patriots vs. Bills?
The over/under line for the Patriots vs. Bills at Fanatics Sportsbook is 49.
Where can I find the latest Patriots vs. Bills betting lines?
You can find the latest betting lines for Patriots vs. Bills at Fanatics Sportsbook. Fanatics offers moneyline, spread, and totals markets, as well as team and player prop betting options for every NFL game in 2026.