Texans vs. Colts Odds, Spreads, and Lines

The Houston Texans and Indianapolis Colts will go to head-to-head in this NFL Week 3 game on Sunday afternoon. The game will kick-off at 1:00 p.m. ET, and will be played at the Lucas Oil Stadium.
Below, you'll find the latest Texans vs. Colts odds, spreads and betting lines at Fanatics Sportsbook, along with betting trends and additional game information. There's a wide range of NFL betting guidance, odds, and more at Fanatics Sportsbook.
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Texans vs. Colts Matchup Information
Date: Sunday, Sept. 27, 2026
Time: 1:00 p.m. ET
Location: Lucas Oil Stadium, Indianapolis, IN
TV: CBS
Texans vs. Colts Odds
Houston is the -150 moneyline favorite against the Colts at Fanatics Sportsbook, with Indianapolis +125 moneyline outsiders. Fanatics Sportsbook is offering point spread markets, totals lines, and prop markets for the game.
Texans vs. Colts Moneyline Odds
- Texans Moneyline -150
- Colts Moneyline +125
The above odds are correct at the time of writing, see below for live odds
Texans vs. Colts Spread Odds
- Colts +2.5 +100
- Texans -2.5 -120
- Colts +6.5 -220
- Texans -6.5 +170
- Colts -1.5 +145
- Texans +1.5 -180
Texans vs. Colts Over/Under Odds
- Over 42.5 -110
- Under 42.5 -110
- Over 37.5 -190
- Under 37.5 +150
- Over 47.5 +150
- Under 47.5 -190
Texans vs. Colts Player Prop Odds
Jonathan Taylor is the most likely scorer in the anytime touchdown market at Fanatics Sportsbook, at odds of -150. David Montgomery and Woody Marks are next on the board. See the latest Daniel Jones odds and C.J. Stroud odds ahead of kickoff.
Fanatics Sportsbook is offering a range of additional player prop markets for the Texans vs. Colts, including passing touchdowns, receiving yards, rushing yards, receptions, and more.
Texans vs. Colts Anytime Touchdown Scorer Odds
- Jonathan Taylor -150
- David Montgomery -105
- Woody Marks +225
- Dalton Schultz +235
- Josh Downs +235
- Tyler Warren +250
Texans vs. Colts +EV Bets
Below are the highest positive expected value bets for the Texans vs. Colts game at Fanatics Sportsbook:
- Jonathan Taylor Anytime Touchdown Scorer (EV 41.07%)
- Tyler Warren Anytime Touchdown Scorer (EV 19.53%)
- Indianapolis Colts +2.5 Points (EV 8.76%)
Texans vs. Colts Odds FAQs
What are the latest odds for Texans vs. Colts?
The Texans are moneyline favorites at -150, the Colts are moneyline outsiders at +125. The point spread line is set at 2.5, with the over/under total line at 42.5 at Fanatics Sportsbook.
Who is favored to win Texans vs. Colts?
The Texans are favored to win against the Colts with moneyline odds of -150, which implies a 60% win probability.
What is the point spread for Texans vs. Colts?
The point spread for the Texans vs. Colts is 2.5 at Fanatics Sportsbook, with Indianapolis at +2.5 and Houston at -2.5.
What is the over/under for Texans vs. Colts?
The over/under line for the Texans vs. Colts at Fanatics Sportsbook is 42.5.
Where can I find the latest Texans vs. Colts betting lines?
You can find the latest betting lines for Texans vs. Colts at Fanatics Sportsbook. Fanatics offers moneyline, spread, and totals markets, as well as team and player prop betting options for every NFL game in 2026.