49ers vs. Seahawks Odds, Spreads, and Lines
The San Francisco 49ers and Seattle Seahawks will go to head-to-head in this NFL Week 5 game on Sunday afternoon. The game will kick-off at 4:25 p.m. ET, and will be played at Lumen Field.
Below, you'll find the latest 49ers vs. Seahawks odds, spreads and betting lines at Fanatics Sportsbook, along with betting trends and additional game information. There's a wide range of NFL betting guidance, odds, and more at Fanatics Sportsbook.
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49ers vs. Seahawks Matchup Information
Date: Sunday, Oct. 11, 2026
Time: 4:25 p.m. ET
Location: Lumen Field, Seattle, WA
TV: FOX
49ers vs. Seahawks Odds
Seattle is the -170 moneyline favorite against the 49ers at Fanatics Sportsbook, with San Francisco +140 moneyline outsiders. Fanatics Sportsbook is offering point spread markets, totals lines, and prop markets for the game.
49ers vs. Seahawks Moneyline Odds
- Seahawks Moneyline -170
- 49ers Moneyline +140
The above odds are correct at the time of writing, see below for live odds
49ers vs. Seahawks Spread Odds
- 49ers +3.5 -105
- Seahawks -3.5 -115
- 49ers +8.5 -280
- Seahawks -8.5 +210
- 49ers -1.5 +155
- Seahawks +1.5 -195
49ers vs. Seahawks Over/Under Odds
- Over 46 -110
- Under 46 -110
- Over 51 +150
- Under 51 -190
- Over 41 -195
- Under 41 +155
49ers vs. Seahawks Player Prop Odds
Christian McCaffrey is the most likely scorer in the anytime touchdown market at Fanatics Sportsbook, at odds of -165. Emanuel Wilson and Jaxon Smith-Njigba are next on the board. See the latest Brock Purdy odds and Sam Darnold odds ahead of kickoff.
Fanatics Sportsbook is offering a range of additional player prop markets for the 49ers vs. Seahawks game, including passing touchdowns, receiving yards, rushing yards, receptions, and more.
49ers vs. Seahawks Anytime Touchdown Scorer Odds
- Christian McCaffrey -165
- Emanuel Wilson -130
- Jaxon Smith-Njigba +100
- George Kittle +175
- Mike Evans +180
49ers vs. Seahawks +EV Bets
Below are the highest positive expected value bets for the 49ers vs. Seahawks game at Fanatics Sportsbook:
- Sam Darnold Over 5.5 Rushing Yards (EV 50.3%)
- San Francisco 49ers +2.5 Spread (EV 23.58%)
- George Kittle Anytime Touchdown Scorer (EV 22.46%)
- San Francisco 49ers Moneyline (EV 22.4%)
- Brock Purdy Over 220.5 Passing Yards (EV 20.9%)
49ers vs. Seahawks Odds FAQs
What are the latest odds for 49ers vs. Seahawks?
The Seahawks are moneyline favorites at -170, the 49ers are moneyline outsiders at +140. The point spread line is set at 3.5, with the over/under total line at 46 at Fanatics Sportsbook.
Who is favored to win 49ers vs. Seahawks?
The Seahawks are favored to win against the 49ers with moneyline odds of -170, which implies a 62.96% win probability.
What is the point spread for 49ers vs. Seahawks?
The point spread for the 49ers vs. Seahawks is 3.5 at Fanatics Sportsbook, with Seattle at -3.5 and San Francisco at +3.5.
What is the over/under for 49ers vs. Seahawks?
The over/under line for the 49ers vs. Seahawks at Fanatics Sportsbook is 46.
Where can I find the latest 49ers vs. Seahawks betting lines?
You can find the latest betting lines for 49ers vs. Seahawks at Fanatics Sportsbook. Fanatics offers moneyline, spread, and totals markets, as well as team and player prop betting options for every NFL game in 2026.