Bills vs. Rams Odds, Spreads, and Lines
The Buffalo Bills and Los Angeles Rams will go to head-to-head in this NFL Week 5 game on Monday night. The game will kick-off at 8:15 p.m. ET, and will be played at SoFi Stadium.
Below, you'll find the latest Bills vs. Rams odds, spreads and betting lines at Fanatics Sportsbook, along with betting trends and additional game information. There's a wide range of NFL betting guidance, odds, and more at Fanatics Sportsbook.
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Bills vs. Rams Matchup Information
Date: Monday, Oct. 12, 2026
Time: 8:15 p.m. ET
Location: SoFi Stadium, Inglewood, CA
TV: ESPN/ABC
Bills vs. Rams Odds
Los Angeles is the -175 moneyline favorite against the Bills at Fanatics Sportsbook, with Buffalo +145 moneyline outsiders. Fanatics Sportsbook is offering point spread markets, totals lines, and prop markets for the game.
Bills vs. Rams Moneyline Odds
- Rams Moneyline -175
- Bills Moneyline +145
The above odds are correct at the time of writing, see below for live odds
Bills vs. Rams Spread Odds
- Bills +3 -105
- Rams -3 -115
- Bills +8.5 -280
- Rams -8.5 +210
- Bills -1.5 +160
- Rams +1.5 -205
Bills vs. Rams Over/Under Odds
- Over 54 -110
- Under 54 -110
- Over 59 +145
- Under 59 -180
- Over 49 -190
- Under 49 +150
Bills vs. Rams Player Prop Odds
Kyren Williams is the most likely scorer in the anytime touchdown market at Fanatics Sportsbook, at odds of -195. Puka Nacua and Josh Allen are next on the board. See the latest Josh Allen odds and Matthew Stafford odds ahead of kickoff.
Fanatics Sportsbook is offering a range of additional player prop markets for the Bills vs. Rams game, including passing touchdowns, receiving yards, rushing yards, receptions, and more.
Bills vs. Rams Anytime Touchdown Scorer Odds
- Kyren Williams -195
- Puka Nacua -145
- Josh Allen -130
- James Cook -115
- Davante Adams -110
Bills vs. Rams +EV Bets
Below are the highest positive expected value bets for the Bills vs. Rams game at Fanatics Sportsbook:
- Matthew Stafford Over 23.5 Passing Completions (EV 37.26%)
- Buffalo Bills +2.5 Spread (EV 21.26%)
- Kyren Williams Over 20.5 Receiving Yards (EV 20.04%)
- Kyren Williams Anytime Touchdown Scorer (EV 18.74%)
- Buffalo Bills Moneyline (EV 17.6%)
Bills vs. Rams Odds FAQs
What are the latest odds for Bills vs. Rams?
The Rams are moneyline favorites at -175, the Bills are moneyline outsiders at +145. The point spread line is set at 3, with the over/under total line at 54 at Fanatics Sportsbook.
Who is favored to win Bills vs. Rams?
The Rams are favored to win against the Bills with moneyline odds of -175, which implies a 63.64% win probability.
What is the point spread for Bills vs. Rams?
The point spread for the Bills vs. Rams is 3 at Fanatics Sportsbook, with Los Angeles at -3 and Buffalo at +3.
What is the over/under for Bills vs. Ramss?
The over/under line for the Bills vs. Rams at Fanatics Sportsbook is 54.
Where can I find the latest Bills vs. Rams betting lines?
You can find the latest betting lines for Bills vs. Rams at Fanatics Sportsbook. Fanatics offers moneyline, spread, and totals markets, as well as team and player prop betting options for every NFL game in 2026.