Cardinals vs. Rams Odds, Spreads, and Lines
The Arizona Cardinals and Los Angeles Rams will go to head-to-head in this NFL Week 6 game on Sunday afternoon. The game will kick-off at 4:05 p.m. ET, and will be played at SoFi Stadium.
Below, you'll find the latest Cardinals vs. Rams odds, spreads and betting lines at Fanatics Sportsbook, along with betting trends and additional game information. There's a wide range of NFL betting guidance, odds, and more at Fanatics Sportsbook.
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Cardinals vs. Rams Matchup Information
Date: Sunday, Oct. 18, 2026
Time: 4:05 p.m. ET
Location: SoFi Stadium, Inglewood, CA
TV: FOX
Cardinals vs. Rams Odds
Los Angeles is the -900 moneyline favorite against the Cardinals at Fanatics Sportsbook, with Arizona +600 moneyline outsiders. Fanatics Sportsbook is offering point spread markets, totals lines, and prop markets for the game.
Cardinals vs. Rams Moneyline Odds
- Cardinals Moneyline +600
- Rams Moneyline -900
The above odds are correct at the time of writing, see below for live odds
Cardinals vs. Rams Spread Odds
- Rams -12.5 -110
- Cardinals +12.5 -110
- Rams -17.5 +155
- Cardinals +17.5 -195
- Rams -7.5 -195
- Cardinals +7.5 +155
Cardinals vs. Rams Over/Under Odds
- Over 52.5 -110
- Under 52.5 -110
- Over 57.5 +145
- Under 57.5 -180
- Over 47.5 -195
- Under 47.5 +155
Cardinals vs. Rams Player Prop Odds
Kyren Williams is the most likely scorer in the anytime touchdown market at Fanatics Sportsbook, at odds of -245. Puka Nacua and Blake Corum are next on the board. See the latest Jacoby Brissett odds and Matthew Stafford odds ahead of kickoff.
Fanatics Sportsbook is offering a range of additional player prop markets for the Cardinals vs. Rams game, including passing touchdowns, receiving yards, rushing yards, receptions, and more.
Cardinals vs. Rams Anytime Touchdown Scorer Odds
- Kyren Williams -245
- Puka Nacua -110
- Blake Corum +105
- Davante Adams +125
- Jeremiyah Love +125
Cardinals vs. Rams +EV Bets
Below are the highest positive expected value bets for the Cardinals vs. Rams game at Fanatics Sportsbook:
- Under 54.5 Total Points (EV 5.75%)
- Under 53.5 Total Points (EV 4.37%)
- Arizona Cardinals +13.5 Spread (EV 4.21%)
Cardinals vs. Rams Odds FAQs
What are the latest odds for Cardinals vs. Rams?
The Rams are moneyline favorites at -900, the Cardinals are moneyline outsiders at +600. The point spread line is set at 12.5, with the over/under total line at 52.5 at Fanatics Sportsbook.
Who is favored to win Cardinals vs. Rams?
The Rams are favored to win against the Cardinals with moneyline odds of -900, which implies a 90% win probability.
What is the point spread for Cardinals vs. Rams?
The point spread for the Cardinals vs. Rams is 12.5 at Fanatics Sportsbook, with Los Angeles at -12.5 and Arizona at +12.5.
What is the over/under for Cardinals vs. Rams?
The over/under line for the Cardinals vs. Rams at Fanatics Sportsbook is 52.5.
Where can I find the latest Cardinals vs. Rams betting lines?
You can find the latest betting lines for Cardinals vs. Rams at Fanatics Sportsbook. Fanatics offers moneyline, spread, and totals markets, as well as team and player prop betting options for every NFL game in 2026.