Commanders vs. 49ers Odds, Spreads, and Lines
The Washington Commanders and San Francisco 49ers will go to head-to-head in this NFL Week 6 game on Monday night. The game will kick-off at 8:15 p.m. ET, and will be played at Levi's Stadium.
Below, you'll find the latest Commanders vs. 49ers odds, spreads and betting lines at Fanatics Sportsbook, along with betting trends and additional game information. There's a wide range of NFL betting guidance, odds, and more at Fanatics Sportsbook.
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Commanders vs. 49ers Matchup Information
Date: Monday, Oct. 19, 2026
Time: 8:15 p.m. ET
Location: Levi's Stadium, San Francisco, CA
TV: ESPN
Commanders vs. 49ers Odds
San Francisco is the -400 moneyline favorite against the Commanders at Fanatics Sportsbook, with Washington +310 moneyline outsiders. Fanatics Sportsbook is offering point spread markets, totals lines, and prop markets for the game.
Commanders vs. 49ers Moneyline Odds
- 49ers Moneyline -400
- Commanders Moneyline +310
The above odds are correct at the time of writing, see below for live odds
Commanders vs. 49ers Spread Odds
- 49ers -7.5 -110
- Commanders +7.5 -110
- 49ers -12.5 +160
- Commanders +12.5 -205
- 49ers -2.5 -310
- Commanders +2.5 +230
Commanders vs. 49erss Over/Under Odds
- Over 50.5 -110
- Under 50.5 -110
- Over 55.5 +155
- Under 55.5 -195
- Over 45.5 -190
- Under 45.5 +150
Commanders vs. 49ers Player Prop Odds
Christian McCaffrey is the most likely scorer in the anytime touchdown market at Fanatics Sportsbook, at odds of -285. Mike Evans and George Kittle are next on the board. See the latest Jayden Daniels odds and Brock Purdy odds ahead of kickoff.
Fanatics Sportsbook is offering a range of additional player prop markets for the Commanders vs. 49ers game, including passing touchdowns, receiving yards, rushing yards, receptions, and more.
Commanders vs. 49ers Anytime Touchdown Scorer Odds
- Christian McCaffrey -285
- Mike Evans -130
- George Kittle +110
- Jacory Croskey-Merritt +180
- Terry McLaurin +190
Commanders vs. 49ers +EV Bets
Below are the highest positive expected value bets for the Commanders vs. 49ers game at Fanatics Sportsbook:
- Washington Commanders Moneyline (EV 27.1%)
- Chigoziem Okonkwo Anytime Touchdown Scorer (EV 23.48%)
- Stefon Diggs Anytime Touchdown Scorer (EV 14.87%)
- Washington Commanders +6.5 Spread (EV 13.35%)
- Jayden Daniels Anytime Touchdown Scorer (EV 9.91%)
Commanders vs. 49ers Odds FAQs
What are the latest odds for Commanders vs. 49ers?
The 49ers are moneyline favorites at -400, the Commanders are moneyline outsiders at +310. The point spread line is set at 7.5, with the over/under total line at 50.5 at Fanatics Sportsbook.
Who is favored to win Commanders vs. 49ers?
The 49ers are favored to win against the Commanders with moneyline odds of -400, which implies a 80% win probability.
What is the point spread for Commanders vs. 49ers?
The point spread for the Commanders vs. 49ers is 7.5 at Fanatics Sportsbook, with San Francisco at -7.5 and Washington at +7.5.
What is the over/under for Commanders vs. 49ers?
The over/under line for the Commanders vs. 49ers at Fanatics Sportsbook is 50.5.
Where can I find the latest Commanders vs. 49ers betting lines?
You can find the latest betting lines for Commanders vs. 49ers at Fanatics Sportsbook. Fanatics offers moneyline, spread, and totals markets, as well as team and player prop betting options for every NFL game in 2026.