Lions vs. Cardinals Odds, Spreads, and Lines
The Detroit Lions and Arizona Cardinals will go to head-to-head in this NFL Week 5 game on Sunday afternoon. The game will kick-off at 4:25 p.m. ET, and will be played at State Farm Stadium.
Below, you'll find the latest Lions vs. Cardinals odds, spreads and betting lines at Fanatics Sportsbook, along with betting trends and additional game information. There's a wide range of NFL betting guidance, odds, and more at Fanatics Sportsbook.
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Lions vs. Cardinals Matchup Information
Date: Sunday, Oct. 11, 2026
Time: 4:25 p.m. ET
Location: State Farm Stadium, Glendale, AZ
TV: FOX
Lions vs. Cardinals Odds
Detroit is the -260 moneyline favorite against the Cardinals at Fanatics Sportsbook, with Arizona +210 moneyline outsiders. Fanatics Sportsbook is offering point spread markets, totals lines, and prop markets for the game.
Lions vs. Cardinals Moneyline Odds
- Lions Moneyline -260
- Cardinals Moneyline +210
The above odds are correct at the time of writing, see below for live odds
Lions vs. Cardinals Spread Odds
- Cardinals +5.5 -110
- Lions -5.5 -110
- Cardinals +10.5 -250
- Lions -10.5 +190
- Cardinals +0.5 +175
- Lions -0.5 -225
Lions vs. Cardinals Over/Under Odds
- Over 54.5 -110
- Under 54.5 -110
- Over 59.5 +150
- Under 59.5 -190
- Over 49.5 -195
- Under 49.5 +155
Lions vs. Cardinals Player Prop Odds
Jahmyr Gibbs is the most likely scorer in the anytime touchdown market at Fanatics Sportsbook, at odds of -450. Jeremiyah Love and Amon-Ra St. Brown are next on the board. See the latest Jacoby Brissett odds and Jared Goff odds ahead of kickoff.
Fanatics Sportsbook is offering a range of additional player prop markets for the Lions vs. Cardinals game, including passing touchdowns, receiving yards, rushing yards, receptions, and more.
Lions vs. Cardinals Anytime Touchdown Scorer Odds
- Jahmyr Gibbs -450
- Jeremiyah Love -145
- Amon-Ra St. Brown -145
- Trey McBride +105
- Jameson Williams +165
Lions vs. Cardinals +EV Bets
Below are the highest positive expected value bets for the Lions vs. Cardinals game at Fanatics Sportsbook:
- Jeremiyah Love Over 2.5 Receptions (EV 19.9%)
- Jared Goff Over 34.5 Passing Attempts (EV 18.82%)
- Amon-Ra St. Brown Anytime Touchdown Scorer (EV 15.98%)
- Kendrick Bourne Over 2.5 Receptions (EV 14.56%)
- Jacoby Brissett Over 5.5 Rushing Yards (EV 14.11%)
Lions vs. Cardinals Odds FAQs
What are the latest odds for Lions vs. Cardinals?
The Lions are moneyline favorites at -260, the Cardinals are moneyline outsiders at +210. The point spread line is set at 5.5, with the over/under total line at 54.5 at Fanatics Sportsbook.
Who is favored to win Lions vs. Cardinals?
The Lions are favored to win against the Cardinals with moneyline odds of -260, which implies a 72.22% win probability.
What is the point spread for Lions vs. Cardinals?
The point spread for the Lions vs. Cardinals is 5.5 at Fanatics Sportsbook, with Detroit at -5.5 and Arizona at +5.5.
What is the over/under for Lions vs. Cardinals?
The over/under line for the Lions vs. Cardinals at Fanatics Sportsbook is 54.5.
Where can I find the latest Lions vs. Cardinals betting lines?
You can find the latest betting lines for Lions vs. Cardinals at Fanatics Sportsbook. Fanatics offers moneyline, spread, and totals markets, as well as team and player prop betting options for every NFL game in 2026.