Lions vs. Panthers Odds, Spreads, and Lines
The Detroit Lions and Carolina Panthers will go to head-to-head in this NFL Week 4 game on Sunday night. The game will kick-off at 8:20 p.m. ET, and will be played at the Bank of America Stadium.
Below, you'll find the latest Lions vs. Panthers odds, spreads and betting lines at Fanatics Sportsbook, along with betting trends and additional game information. There's a wide range of NFL betting guidance, odds, and more at Fanatics Sportsbook.
New to Fanatics Sportsbook? The Fanatics Sportsbook promo code is FAN350. New customers who sign up with code FAN350 get $350 in FanCash after they wager $20 or more at odds of ‑500 or longer within your first 7 days. Available to new users 21+.
Lions vs. Panthers Matchup Information
Date: Sunday, Oct. 4, 2026
Time: 8:20 p.m. ET
Location: Bank of America Stadium, Charlotte, NC
TV: NBC/Peacock
Lions vs. Panthers Odds
Detroit is the -195 moneyline favorite against the Panthers at Fanatics Sportsbook, with Carolina +160 moneyline outsiders. Fanatics Sportsbook is offering point spread markets, totals lines, and prop markets for the game.
Lions vs. Panthers Moneyline Odds
- Lions Moneyline -195
- Panthers Moneyline +160
The above odds are correct at the time of writing, see below for live odds
Lions vs. Panthers Spread Odds
- Panthers +3.5 -105
- Lions -3.5 -115
- Panthers +8.5 -235
- Lions -8.5 +180
- Panthers -2.5 +190
- Lions +2.5 -250
Lions vs. Panthers Over/Under Odds
- Over 51.5 -105
- Under 51.5 -115
- Over 56.5 +150
- Under 56.5 -190
- Over 46.5 -190
- Under 46.5 +150
Lions vs. Panthers Player Prop Odds
Jahmyr Gibbs is the most likely scorer in the anytime touchdown market at Fanatics Sportsbook, at odds of -300. Chuba Hubbard and Amon-Ra St. Brown are next on the board. See the latest Jared Goff odds and Bryce Young odds ahead of kickoff.
Fanatics Sportsbook is offering a range of additional player prop markets for the Lions vs. Panthers game, including passing touchdowns, receiving yards, rushing yards, receptions, and more.
Lions vs. Panthers Anytime Touchdown Scorer Odds
- Jahmyr Gibbs -300
- Chuba Hubbard -130
- Amon-Ra St. Brown -120
- Tetairoa McMillan +165
- Sam LaPorta +200
- Jalen Coker +215
Lions vs. Panthers +EV Bets
Below are the highest positive expected value bets for the Lions vs. Panthers game at Fanatics Sportsbook:
- Jalen Coker Anytime Touchdown Scorer (EV 46.03%)
- Amon-Ra St. Brown Anytime Touchdown Scorer (EV 30.86%)
- Jared Goff Over 255.5 Passing Yards (EV 23.79%)
- Jared Goff Over 260.5 Passing Yards (EV 22.03%)
- Darren Waller Anytime Touchdown Scorer (EV 20.51%)
Lions vs. Panthers Odds FAQs
What are the latest odds for Lions vs. Panthers?
The Lions are moneyline favorites at -195, the Panthers are moneyline outsiders at +160. The point spread line is set at 3.5, with the over/under total line at 51.5 at Fanatics Sportsbook.
Who is favored to win Lions vs. Panthers?
The Lions are favored to win against the Panthers with moneyline odds of -195, which implies a 66.10% win probability.
What is the point spread for Lions vs. Panthers?
The point spread for the Lions vs. Panthers is 3.5 at Fanatics Sportsbook, with Carolina at +3.5 and Detroit at -3.5.
What is the over/under for Lions vs. Panthers?
The over/under line for the Lions vs. Panthers at Fanatics Sportsbook is 51.5.
Where can I find the latest Lions vs. Panthers betting lines?
You can find the latest betting lines for Lions vs. Panthers at Fanatics Sportsbook. Fanatics offers moneyline, spread, and totals markets, as well as team and player prop betting options for every NFL game in 2026.