NFL Preseason Week 2 Odds, Spreads, and Lines
NFL preseason football continues this week as all 32 teams take the field for the second full slate of exhibition action ahead of the 2026 regular season. Preseason games give bettors a chance to evaluate roster depth, quarterback battles, and emerging talent across the league.
Below, you'll find the latest NFL preseason Week 2 odds, spreads and betting lines at Fanatics Sportsbook, along with matchup information for every game on the schedule. There's a wide range of NFL betting guidance, odds, and more at Fanatics Sportsbook.
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NFL Preseason Week 2 Latest Odds
Las Vegas Raiders @ Houston Texans Odds, Spread, and Betting Lines
Date/Time: Aug. 20, 2026 | 8:00 p.m. ET
Location: NRG Stadium in Houston, TX
- Spread: Texans -2, Raiders +2
- Moneyline: Texans -130, Raiders +110
- O/U: 40
The Raiders and Texans continue their 2026 preseason schedules at Reliant Stadium on Thursday night. Las Vegas opened its preseason schedule with a defeat against the Arizona Cardinals, while the Texans suffered a 7-27 loss against the Chargers.
Las Vegas enters the 2026 season under new head coach Klint Kubiak, and new quarterback Fernando Mendoza. The Texans will be looking to build on a 12-win season in 2025.
San Francisco 49ers @ Los Angeles Chargers Odds, Spread, and Betting Lines
Date/Time: Aug. 20, 2026 | 9:00 p.m. ET
Location: Sofi Stadium in Inglewood, CA
- Spread: Chargers -2, 49ers +2
- Moneyline: Chargers -120, 49ers +100
- O/U: 38.5
The 49ers and Chargers meet in their second preseason games of 2026 on Thursday night. San Francisco lost to Tennessee in its opening preseason game, while the Chargers defeated the Texans.
San Francisco will use this game to assess their roster depth ahead of the start of the season, as the 49ers chase a first NFC West title since 2023. The Chargers have gone 11-6 in consecutive seasons.
New York Jets @ Pittsburgh Steelers Odds, Spread, and Betting Lines
Date/Time: Aug. 21, 2026 | 7:00 p.m. ET
Location: Acrisure Stadium in Pittsburgh, PA
- Spread: Steelers -3.5, Jets +3.5
- Moneyline: Steelers -175, Jets +145
- O/U: 39
The Jets and Steelers continue their 2026 preseason schedules on Friday night in Pittsburgh. This is a good opportunity for both teams to assess their roster depth ahead of the new season.
New York were defeated 24-16 by Tampa Bay in its first preseason game, while Pittsburgh cruised past the Green Bay Packers 28-9, with Drew Allar posting two TDs.
Carolina Panthers @ Jacksonville Jaguars Odds, Spread, and Betting Lines
Date/Time: Aug. 21, 2026 | 7:30 p.m. ET
Location: Everbank Stadium in Jacksonville, FL
- Spread: Jaguars -2.5, Panthers +2.5
- Moneyline: Jaguars -140, Panthers +115
- O/U: 39
The Panthers travel to Jacksonville to face the Jaguars in their second preseason game. Both teams have playoff ambitions for 2026, with each expected to assess their rookies and backups in this game.
Carolina was defeated 29-14 at the Bills in its opening preseason game, while Jacksonville won against the New Orleans Saints.
Green Bay Packers @ Denver Broncos Odds, Spread, and Betting Lines
Date/Time: Aug. 21, 2026 | 9:00 p.m. ET
Location: Empower Field in Denver, CO
- Spread: Broncos -7, Packers +7
- Moneyline: Broncos -350, Packers +275
- O/U: 39.5
The Packers and Broncos meet in this 2026 preseason game on Friday night. This game will be about assessing their backup players for both franchises.
Green Bay suffered a 28-9 defeat to the Steelers in its opening preseason game, as Denver defeated Atlanta 27-7 with an impressive performance.
Washington Commanders @ Detroit Lions Odds, Spread, and Betting Lines
Date/Time: Aug. 22, 2026 | 12:00 p.m. ET
Location: Ford Field in Detroit, MI
- Spread: Lions -4.5, Commanders +4.5
- Moneyline: Lions -215, Commanders +175
- O/U: 37.5
The Commanders and Lions continue their preseason schedules in Detroit on Saturday afternoon. Washington cruised to a 20-7 victory against Miami in its opening preseason game, while Detroit suffered a narrow defeat against Cincinnati.
Washington have outside playoff hopes for 2026, but will need to improve on their 5-12 record from 2025. The Lions are one of the NFC's top contenders and a legitimate Super Bowl LXI threat.
Buffalo Bills @ Cleveland Browns Odds, Spread, and Betting Lines
Date/Time: Aug. 22, 2026 | 1:00 p.m. ET
Location: Huntington Bank Field in Cleveland, OH
- Spread: Browns -3, Bills +3
- Moneyline: Browns -155, Bills +130
- O/U: 37
The Bills travel to face the Browns in this preseason game. Buffalo opened its 2026 preseason schedule with a 29-14 win against Carolina, while the Browns lost the Bears in their preseason opener.
Buffalo enters the 2026 season with high expectations under new head coach Joe Brady. Cleveland also has a new head coach for the new season in Todd Monken, who will be looking to improve an offense that struggled for consistency last season.
Baltimore Ravens @ Minnesota Vikings Odds, Spread, and Betting Lines
Date/Time: Aug. 22, 2026 | 1:00 p.m. ET
Location: U.S. Bank Stadium in Minneapolis, MN
- Spread: Vikings -3, Ravens +3
- Moneyline: Vikings -165, Ravens +135
- O/U: 37.5
The Vikings host the Ravens in this preseason game on Saturday afternoon. Both teams recorded victories in their opening preseason games, Minnesota defeated the Giants and Baltimore won in impressive style against Philadelphia.
The Vikings are expected to be one of the NFC's playoff contenders this season, while Baltimore has its eyes on Super Bowl LXI.
Atlanta Falcons @ Indianapolis Colts Odds, Spread, and Betting Lines
Date/Time: Aug. 22, 2026 | 1:00 p.m. ET
Location: Lucas Oil Stadium in Indianapolis, IN
- Spread: Colts -3.5, Falcons +3.5
- Moneyline: Colts -200, Falcons +165
- O/U: 37
The Falcons travel to face the Colts in this preseason game. Atlanta was defeated 27-7 in its opening preseason game against the Broncos, while Indianapolis tied with New England.
Both franchises will be aiming for a playoff berth in 2026, and this game will provide a good opportunity to assess roster depth.
New York Giants @ Miami Dolphins Odds, Spread, and Betting Lines
Date/Time: Aug. 22, 2026 | 4:00 p.m. ET
Location: Hard Rock Stadium in Opa Locka, FL
- Spread: Giants -2.5, Dolphins +2.5
- Moneyline: Giants -140, Dolphins +115
- O/U: 38
The Dolphins host the Giants on Saturday night in this preseason game. Both teams were defeated in their Week 1 preseason games, Miami lost against Washington and the Giants lost to the Vikings.
New York is expected to be fringe playoff contenders in 2026, while Miami are set for a rebuilding season. This game will provide an opportunity for the Dolphins to assess backups and roster depth.
New Orleans Saints @ Los Angeles Rams Odds, Spread, and Betting Lines
Date/Time: Aug. 22, 2026 | 4:00 p.m. ET
Location: SoFi Stadium in Inglewood, CA
- Spread: Saints -1, Rams +1
- Moneyline: Saints -140, Rams +115
- O/U: 37.5
The Rams host the Saints on Saturday afternoon in this preseason game. Los Angeles defeated Kansas City in its opening preseason game. New Orleans suffered a 24-20 defeat against Jacksonville.
The Rams are preseason Super Bowl LXI favorites for 2026, while New Orleans are expected to be in the mix for an NFC playoff spot this season.
Philadelphia Eagles @ New England Patriots Odds, Spread, and Betting Lines
Date/Time: Aug. 22, 2026 | 7:00 p.m. ET
Location: Gillette Stadium in Foxborough, MA
- Spread: Eagles -2.5, Patriots +2.5
- Moneyline: Eagles -140, Patriots +115
- O/U: 38
The Eagles continue their preseason schedule at New England in Week 2. Philadelphia was defeated 24-7 against Baltimore in its first preseason game of 2026, while the Patriots tied 13-13 with Indianapolis.
Philadelphia is a legitimate Super Bowl LXI contender in 2026, and enter the season with a new offensive coordinator in Sean Mannion. New England lost to the Seattle Seahawks in Super Bowl LX last season, and enter a second season under head coach Mike Vrabel.
Chicago Bears @ Cincinnati Bengals Odds, Spread, and Betting Lines
Date/Time: Aug. 22, 2026 | 7:00 p.m. ET
Location: Paycor Stadium in Cincinnati, OH
- Spread: Bears -2.5, Bengals +2.5
- Moneyline: Bears -140, Bengals +115
- O/U: 37
The Bears travel to face the Bengals in this preseason game in Cincinnati. Chicago impressed in a 34-10 win against the Browns in its Week 1 preseason game, while Cincinnati defeated Detroit.
Both of these teams have posted the same win total number for 2026 at 9.5, with each expected to be playoff contenders in their respective divisions.
Kansas City Chiefs @ Tampa Bay Buccaneers Odds, Spread, and Betting Lines
Date/Time: Aug. 22, 2026 | 7:30 p.m. ET
Location: Raymond James Stadium in Tampa, FL
- Spread: Buccaneers -5.5, Chiefs +5.5
- Moneyline: Buccaneers -245, Chiefs +200
- O/U: 37
The Chiefs travel to face the Buccaneers in this preseason clash on Saturday night. Kansas City opened its preseason schedule with a defeat against Super Bowl LXI favorites the Rams, while Tampa Bay defeated the New York Jets.
Kansas City is boosted by the return of star quarterback Patrick Mahomes in 2026. Tampa Bay enters the campaign looking to reclaim the NFC South crown after its streak of four consecutive division titles came to an end in 2025.
Dallas Cowboys @ Arizona Cardinals Odds, Spread, and Betting Lines
Date/Time: Aug. 22, 2026 | 10:00 p.m. ET
Location: State Farm Stadium in Glendale, AZ
- Spread: Cardinals -1, Cowboys +1
- Moneyline: Cardinals -130, Cowboys +110
- O/U: 38
The Cardinals host the Cowboys on Saturday night in this 2026 preseason game. With roster decisions still to be made by both teams, expect backups and rookies to be given plenty of snaps in this clash.
Arizona defeated Las Vegas in its Week 1 preseason game, while the Cowboys won against Super Bowl LX champions Seattle.
Seattle Seahawks @ Tennessee Titans Odds, Spread, and Betting Lines
Date/Time: Aug. 23, 2026 | 8:00 p.m. ET
Location: Nissan Stadium in Nashville, TN
- Spread: Titans -3, Seahawks +3
- Moneyline: Titans -155, Seahawks +130
- O/U: 38
The Seahawks travel to face the Titans on Sunday night. Seattle was defeated 17-7 against the Cowboys in its preseason opener, and Tennessee defeated the 49ers.
Seattle will be looking to retain its championship in 2026 after winning Super Bowl LX. The Titans have had a 3-14 record in each of the past two seasons and will be looking to make progress in 2026.