NFL Week 1 Odds, Spreads & Betting Lines for Every Game
NFL football is back as the 2026 regular season kicks off with a full Week 1 slate. From a Super Bowl LX rematch between the Patriots and Seahawks to divisional showdowns featuring the Cowboys, Giants, Broncos and Chiefs, bettors have their first opportunity to assess teams in meaningful action and uncover early-season value.
Below, you'll find the latest NFL Week 1 odds, spreads and betting lines at Fanatics Sportsbook, along with matchup information for every game on the schedule. There's a wide range of NFL betting guidance, odds, and more at Fanatics Sportsbook.
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NFL Week 1 Odds
New England Patriots @ Seattle Seahawks Odds, Spread, and Betting Lines
Date/Time: Sept. 9, 2026 | 8:20 p.m. ET
Location: Lumen Field, Seattle, WA
- Spread: Seahawks -3.5, Patriots +3.5
- Moneyline: Seahawks -180, Patriots +150
- O/U: 44.5
The Patriots travel to Seattle for the opening game of the 2026 NFL season, in a rematch of Super Bowl LX. Seattle is -3.5 point spread favorites at Fanatics Sportsbook.
San Francisco 49ers vs. Los Angeles Rams Odds, Spread, and Betting Lines
Date/Time: Sept. 10, 2026 | 8:35 p.m. ET
Location: Melbourne Cricket Ground, Melbourne, VIC, Australia
- Spread: Rams -3.5, 49ers +3.5
- Moneyline: Rams -200, 49ers +165
- O/U: 48.5
San Francisco and Los Angeles kick off their 2026 seasons with a matchup in Melbourne, Australia. The Rams are preseason favorites to win Super Bowl LXI, and are -200 moneyline favorites for this game at Fanatics Sportsbook. Los Angeles won all three of their preseason games.
Chicago Bears @ Carolina Panthers Odds, Spread, and Betting Lines
Date/Time: Sept. 13, 2026 | 1:00 p.m. ET
Location: Bank of America Stadium, Charlotte, NC
- Spread: Bears -3, Panthers +3
- Moneyline: Bears -165, Panthers +135
- O/U: 47
Carolina hosts Chicago in this Week 1 clash. Both of these teams had a 2-1 record across NFL preseason, Chicago defeated Tennessee and Cleveland, while Carolina won vs Houston and Jacksonville. Chicago is favored at -165 on the moneyline at Fanatics Sportsbook.
Cleveland Browns @ Jacksonville Jaguars Odds, Spread, and Betting Lines
Date/Time: Sept. 13, 2026 | 1:00 p.m. ET
Location: EverBank Stadium, Jacksonville, FL
- Spread: Jaguars -8.5, Browns +8.5
- Moneyline: Jaguars -400, Browns +310
- O/U: 40.5
Cleveland faces a difficult Week 1 test on the road against Jacksonville, which enters as a heavy -400 moneyline favorite at Fanatics Sportsbook. This matchup features one of the largest spreads of the Week 1 slate, with the Jaguars listed as 8.5-point favorites over the Browns.
Atlanta Falcons @ Pittsburgh Steelers Odds, Spread, and Betting Lines
Date/Time: Sept. 13, 2026 | 1:00 p.m. ET
Location: Acrisure Stadium, Pittsburgh, PA
- Spread: Steelers -3.5, Falcons +3.5
- Moneyline: Steelers -180, Falcons +150
- O/U: 42
Atlanta faces Pittsburgh in this Week 1 game, with the Steelers -3.5 on the point spread at Fanatics Sportsbook.
New York Jets @ Tennessee Titans Odds, Spread, and Betting Lines
Date/Time: Sept. 13, 2026 | 1:00 p.m. ET
Location: Nissan Stadium, Nashville, TN
- Spread: Titans -1.5, Jets +1.5
- Moneyline: Titans -215, Jets +105
- O/U: 39.5
Tennessee hosts the Jets in this Week 1 matchup, which shapes up as one of the toughest games on the board to predict. New York enters as a slight +105 moneyline underdog, while Tennessee is listed as a 1.5-point favorite on the spread.
Tampa Bay Buccaneers @ Cincinnati Bengals Odds, Spread, and Betting Lines
Date/Time: Sept. 13, 2026 | 1:00 p.m. ET
Location: Paycor Stadium, Cincinnati, OH
- Spread: Bengals -4.5, Buccaneers +4.5
- Moneyline: Bengals -215, Buccaneers +175
- O/U: 50.5
Cincinnati are -215 favorites to win against Tampa Bay in this Week 1 matchup at Fanatics Sportsbook. The Bengals won all three of their preseason games, against Philadelphia, Chicago, and Detroit.
Baltimore Ravens @ Indianapolis Colts Odds, Spread, and Betting Lines
Date/Time: Sept. 13, 2026 | 1:00 p.m. ET
Location: Lucas Oil Stadium, Indianapolis, IN
- Spread: Ravens -3.5, Colts +3.5
- Moneyline: Ravens -180, Colts +150
- O/U: 47.5
Baltimore enters Week 1 as a -180 moneyline favorite at Fanatics Sportsbook. The Ravens had a strong preseason, winning all three games impressively against Washington, Minnesota, and Philadelphia. Baltimore conceded just 13 points across these games. Indianapolis went winless in preseason.
New Orleans Saints @ Detroit Lions Odds, Spread, and Betting Lines
Date/Time: Sept. 13, 2026 | 1:00 p.m. ET
Location: Ford Field, Detroit, MI
- Spread: Lions -7, Saints +7
- Moneyline: Lions -330, Saints +260
- O/U: 50
New Orleans faces a tough opening Week 1 game at Detroit - the Lions are -330 favorites to win this game at Fanatics Sportsbook.
Buffalo Bills @ Houston Texans Odds, Spread, and Betting Lines
Date/Time: Sept. 13, 2026 | 1:00 p.m. ET
Location: Reliant Stadium, Houston, TX
- Spread: Texans -1, Bills +1
- Moneyline: Texans -110, Bills -110
- O/U: 44.5
Buffalo travels to Houston in this highly anticipated Week 1 matchup. This is a difficult game to call, and Fanatics Sportsbook lists both teams at -110 on the moneyline entering Week 1. Buffalo won all three of its preseason games, and Houston lost all three of its preseason games.
Miami Dolphins @ Las Vegas Raiders Odds, Spread, and Betting Lines
Date/Time: Sept. 13, 2026 | 4:25 p.m. ET
Location: Allegiant Stadium, Las Vegas, NV
- Spread: Raiders -3.5, Dolphins +3.5
- Moneyline: Raiders -190, Dolphins +155
- O/U: 40.5
Miami travels to Las Vegas in this Week 1 game, between two teams expected to struggle for wins in 2026. The Raiders are favored at -190 on the moneyline at Fanatics Sportsbook.
Washington Commanders @ Philadelphia Eagles Odds, Spread, and Betting Lines
Date/Time: Sept. 13, 2026 | 4:25 p.m. ET
Location: Lincoln Financial Field, Philadelphia, PA
- Spread: Eagles -4.5, Washington +4.5
- Moneyline: Eagles -235, Washington +190
- O/U: 44
Despite going winless in preseason, Philadelphia is a solid -235 moneyline favorite against Washington at Fanatics Sportsbook.
Arizona Cardinals @ Los Angeles Chargers Odds, Spread, and Betting Lines
Date/Time: Sept. 13, 2026 | 4:25 p.m. ET
Location: SoFi Stadium, Inglewood, CA
- Spread: Chargers -9.5, Cardinals +9.5
- Moneyline: Chargers -525, Cardinals +390
- O/U: 47
The Chargers are strong favorites to defeat Arizona in Week 1, with Los Angeles at -525 on the moneyline at Fanatics Sportsbook. Arizona has posted one of the lowest win totals lines in the NFL for 2026, and is expected to struggle this season.
Green Bay Packers @ Minnesota Vikings Odds, Spread, and Betting Lines
Date/Time: Sept. 13, 2026 | 4:25 p.m. ET
Location: U.S. Bank Stadium, Minneapolis, MN
- Spread: Vikings -1.5, Packers +1.5
- Moneyline: Vikings -120, Packers +100
- O/U: 46
Minnesota hosts Green Bay in this Week 1 matchup on Sunday night. Minnesota enters Week 1 as a slight -120 moneyline favorite at Fanatics Sportsbook.
Dallas Cowboys @ New York Giants Odds, Spread, and Betting Lines
Date/Time: Sept. 13, 2026 | 8:20 p.m. ET
Location: MetLife Stadium, East Rutherford, NJ
- Spread: Cowboys -3, Giants +3
- Moneyline: Cowboys -165, Giants +135
- O/U: 48.5
Dallas opens its 2026 NFL season with a difficult road game against the Giants, but the Cowboys are 3-point favorites at Fanatics Sportsbook. Dallas defeated Super Bowl LX champions Seattle in preseason, as well as Arizona.
Denver Broncos @ Kansas City Chiefs Odds, Spread, and Betting Lines
Date/Time: Sept. 14, 2026 | 8:15 p.m. ET
Location: Arrowhead Stadium, Kansas City, MO
- Spread: Chiefs -2.5, Broncos +2.5
- Moneyline: Chiefs -150, Broncos +125
- O/U: 43.5
The final matchup of Week 1 will see Denver travel to face the Chiefs on Monday night. Kansas City is -150 moneyline favorites at Fanatics Sportsbook, with Denver entering as a slight +125 moneyline underdog. The Chiefs went winless in their preseason games, a tie with Seattle was followed by losses against Tampa Bay and the Rams.