NFL Week 5 Odds, Spreads & Betting Lines for Every NFL Game
The 2026 NFL regular season continues with a full Week 5 slate, with key games including the Tampa Bay Buccaneers @ Dallas Cowboys, San Francisco 49ers @ Seattle Seahawks, and Buffalo Bills @ Los Angeles Rams.
Below, you'll find the latest NFL Week 5 odds, spreads and betting lines at Fanatics Sportsbook, along with matchup information for every game on the schedule. There's a wide range of NFL betting guidance, odds, and more at Fanatics Sportsbook.
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NFL Week 5 Odds
Buccaneers vs. Cowboys Odds, Spread, and Betting Lines
Date/Time: Oct. 8, 2026 | 8:15 p.m. ET
Location: AT&T Stadium, Arlington, TX
- Spread: Buccaneers +10, Cowboys -10
- Moneyline: Buccaneers +420, Cowboys -575
- O/U: 47.5
The Tampa Bay Buccaneers are on the road against Dallas in Week 5 of the NFL season. The Buccaneers are chasing a first win of the season after four losses so far, while Dallas has a 2-2 record ahead of this matchup. See the latest Dak Prescott odds and Baker Mayfield odds ahead of the game.
Eagles vs. Jaguars Odds, Spread, and Betting Lines
Date/Time: Oct. 11, 2026 | 9:30 a.m. ET
Location: Tottenham Hotspur Stadium, London, England
- Spread: Eagles +4.5, Jaguars -4.5
- Moneyline: Eagles +180, Jaguars -220
- O/U: 43
The Jaguars host Philadelphia in this Week 5 matchup. Jacksonville has started the season strongly, with a 3-1 record ahead of this game. The Eagles lost vs. the Rams in Week 4, and have a 2-2 record ahead of this game. See the latest Jalen Hurts odds and Trevor Lawrence odds ahead of the game.
Bears vs. Packers Odds, Spread, and Betting Lines
Date/Time: Oct. 11, 2026 | 1:00 p.m. ET
Location: Lambeau Field, Green Bay, WI
- Spread: Bears -2.5, Packers +2.5
- Moneyline: Bears -140, Packers +115
- O/U: 44.5
The Chicago Bears are on the road against Green Bay on Sunday afternoon. The Bears defeated the Jets in Week 4, taking their record to 3-1 after four games. The Packers won against Tampa in Week 4 - Green Bay has a 2-2 record ahead of this game. See the latest Caleb Williams odds and Jordan Love odds ahead of the game.
Bengals vs. Dolphins Odds, Spread, and Betting Lines
Date/Time: Oct. 11, 2026 | 1:00 p.m. ET
Location: Hard Rock Stadium, Miami Gardens, FL
- Spread: Bengals -7.5, Dolphins +7.5
- Moneyline: Bengals -400, Dolphins +310
- O/U: 42.5
The Dolphins will be chasing a first win of the 2026 season vs. Cincinnati in Week 5. The Bengals are 7.5 point favorites against Miami, and post a 2-2 record after a Week 4 loss to Jacksonville. See the latest Joe Burrow odds and Malik Willis odds ahead of the game.
Browns vs. Jets Odds, Spread, and Betting Lines
Date/Time: Oct. 11, 2026 | 1:00 p.m. ET
Location: MetLife Stadium, East Rutherford, NJ
- Spread: Browns +2, Jets -2
- Moneyline: Browns +110, Jets -130
- O/U: 40
The Cleveland Browns and New York Jets matchup in this Week 5 game at MetLife Stadium. The Browns have a 3-1 record after four games of the season, while the Jets' Week 4 loss vs. Chicago took their record to 1-3. See the latest Deshaun Watson odds and Geno Smith odds ahead of the game.
Texans vs. Titans Odds, Spread, and Betting Lines
Date/Time: Oct. 11, 2026 | 1:00 p.m. ET
Location: Nissan Stadium, Nashville, Tennessee
- Spread: Texans -6.5, Titans +6.5
- Moneyline: Texans -300, Titans +240
- O/U: 39.5
The Houston Texans are on the road against Tennessee in Week 5. The Texans lost against Dallas in Week 4, and post a 0-4 record ahead of Week 5. The Titans are also chasing a first win of the season after four losses so far. See the latest C.J. Stroud odds and Cam Ward odds ahead of the game.
Colts vs. Steelers Odds, Spread, and Betting Lines
Date/Time: Oct. 11, 2026 | 1:00 p.m. ET
Location: Acrisure Stadium, Pittsburgh, PA
- Spread: Steelers -2.5, Colts +2.5
- Moneyline: Steelers -140, Colts +115
- O/U: 44.5
The Pittsburgh Steelers host the Indianapolis Colts in Week 5. The Steelers lost at Cleveland in Week 4, and have a 2-2 record ahead of this matchup. The Colts have won back-to-back games in recent weeks, after losing their opening two games of the season. See the latest Aaron Rodgers odds and Daniel Jones odds ahead of the game.
Raiders vs. Patriots Odds, Spread, and Betting Lines
Date/Time: Oct. 11, 2026 | 1:00 p.m. ET
Location: Gillette Stadium, Foxborough, MA
- Spread: Raiders +3.5, Patriots -3.5
- Moneyline: Raiders +160, Patriots -195
- O/U: 45
The Las Vegas Raiders travel to play against New England on Sunday afternoon. The Raiders faced a first defeat of the season against Kansas City in Week 4, while the Patriots have a 2-2 record ahead of this Week 5 matchup. See the latest Drake Maye odds and Kirk Cousins odds ahead of the game.
Vikings vs. Saints Odds, Spread, and Betting Lines
Date/Time: Oct. 11, 2026 | 1:00 p.m. ET
Location: Caesers Superdrome, New Orleans, LA
- Spread: Vikings -1.5, Saints +1.5
- Moneyline: Vikings -120, Saints +100
- O/U: 42
The New Orleans Saints host the Vikings at Caesers Superdrome in Week 5. The Saints opened with a defeat to Detroit, but won vs. Baltimore in Week 2. Minnesota has won all four games so far this campaign. See the latest Tyler Shough odds and Kyler Murray odds ahead of the game.
Giants vs. Commanders Odds, Spread, and Betting Lines
Date/Time: Oct. 11, 2026 | 1:00 p.m. ET
Location: Northwest Stadium, Summerfield, WA
- Spread: Giants +3, Commanders -3
- Moneyline: Giants +150, Commanders -180
- O/U: 44
The Giants are on the road against Washington in Week 5. New York has a 3-1 record after four games of the campaign, while the Commanders' Week 4 loss vs. Indianapolis took their record to 1-3. See the latest Jaxson Dart odds and Jayden Daniels odds ahead of the game.
Broncos @ Chargers Odds, Spread, and Betting Lines
Date/Time: Oct. 11, 2026 | 4:05 p.m. ET
Location: SoFi Stadium, Inglewood, CA
- Spread: Broncos -3.5, Chargers +3.5
- Moneyline: Broncos -180, Chargers +150
- O/U: 43
The Denver Broncos are on the road against the Chargers in Week 5. Denver has a 2-2 record ahead of this game, while Los Angeles is chasing a first win of the season. See the lates Justin Herbert odds and Bo Nix odds ahead of the game.
Lions @ Cardinals Odds, Spread, and Betting Lines
Date/Time: Oct 11., 2026 | 4:25 p.m. ET
Location: State Farm Stadium, Glendale, AZ
- Spread: Lions -4.5, Cardinals +4.5
- Moneyline: Lions -225, Cardinals +185
- O/U: 54.5
The Arizona Cardinals host the Detroit Lions on Sunday afternoon. The Cardinals' loss at the Giants in Week 4 gives them a 1-3 record ahead of Week 5. Detroit lost on the road at Jacksonville last time out. See the latest Jared Goff odds and Jacoby Brissett odds ahead of the game.
49ers @ Seahawks Odds, Spread, and Betting Lines
Date/Time: Oct. 11, 2026 | 4:25 p.m. ET
Location: Lumen Field, Seattle, WA
- Spread: 49ers +3, Seahawks -3
- Moneyline: 49ers +135, Seahawks -165
- O/U: 47
The 49ers are on the road against Seattle in Week 5. San Francisco boasts a 4-0 record in 2026 so far, while Seattle's Week 4 win against the Chargers took their record to 3-1. See the latest Brock Purdy odds and Sam Darnold odds ahead of the game.
Ravens @ Falcons Odds, Spread, and Betting Lines
Date/Time: Oct. 11, 2026 | 8:20 p.m. ET
Location: Pista Mercedes-Benz, Atlanta, GA
- Spread: Ravens -3.5, Falcons +3.5
- Moneyline: Ravens -205, Falcons +170
- O/U: 47
Atlanta hosts Baltimore in this Week 5 Sunday night game. The Falcons opened with consecutive losses but earned a first season win in Week 3 against Green Bay. The Ravens have a 3-1 record ahead of this matchup. See the latest Lamar Jackson odds and Tua Tagovailoa odds ahead of the game.
Bills @ Rams Odds, Spread, and Betting Lines
Date/Time: Oct. 13, 2026 | 8:15 p.m. ET
Location: SoFi Stadium, Inglewood, CA
- Spread: Rams -2.5, Bills +2.5
- Moneyline: Rams -150, Bills +125
- O/U: 53.5
The Buffalo Bills are on the road against the Rams on Monday night. Buffalo faced a first loss of the season against New England in Week 4, while the Rams took their record to 2-2 after a win at Philadelphia. See the latest Matthew Stafford odds and Josh Allen odds ahead of the game.