NFL Week 6 Odds, Spreads & Betting Lines for Every NFL Game
The 2026 NFL regular season continues with a full Week 6 slate, with key games including the Dallas Cowboys @ Green Bay Packers, Buffalo Bills @ Las Vegas Raiders, and Washington Commanders @ San Francisco 49ers.
Below, you'll find the latest NFL Week 6 odds, spreads and betting lines at Fanatics Sportsbook, along with matchup information for every game on the schedule. There's a wide range of NFL betting guidance, odds, and more at Fanatics Sportsbook.
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NFL Week 6 Odds
Seahawks vs. Broncos Odds, Spread, and Betting Lines
Date/Time: Oct. 15, 2026 | 8:15 p.m. ET
Location: Empower Field at Mile High, Denver, CO
- Spread: Seahawks -3, Broncos +3
- Moneyline: Seahawks -155, Broncos +130
- O/U: 41
Seattle is on the road against Denver in Week 6. Both teams post a 3-2 record ahead of this Thursday night matchup, the Seahawks lost vs. San Francisco in Week 5, while the Broncos won at the Chargers. See the latest Sam Darnold odds and Bo Nix odds ahead of the game.
Texans vs. Jaguars Odds, Spread, and Betting Lines
Date/Time: Oct. 18, 2026 | 9:30 a.m. ET
Location: Wembley Stadium, London, England
- Spread: Texans +2.5, Jaguars -2.5
- Moneyline: Texans +120, Jaguars -145
- O/U: 43.5
The Houston Texans and Jacksonville Jaguars will meet at Wembley Stadium in London on Sunday morning. Houston has started the season poorly, with a 1-4 record after five games. The Jaguars are favored to win this matchup after winning each of their past three games. See the latest C.J. Stroud odds and Trevor Lawrence odds ahead of the game.
Ravens vs. Browns Odds, Spread, and Betting Lines
Date/Time: Oct. 18, 2026 | 1:00 p.m. ET
Location: Huntington Bank Field, Cleveland, OH
- Spread: Ravens -4.5, Browns +4.5
- Moneyline: Ravens -235, Browns +190
- O/U: 41
The Cleveland Browns host the Baltimore Ravens in this Week 6 clash. Baltimore has started the season strongly, with a 4-1 record heading into Week 6. The Browns are 4.5 point underdogs in this game after a 17-12 loss to the Jets in Week 5. See the latest Deshaun Watson odds and Lamar Jackson odds ahead of the game.
Panthers vs. Eagles Odds, Spread, and Betting Lines
Date/Time: Oct. 18, 2026 | 1:00 p.m. ET
Location: Lincoln Financial Field, Philadelphia, PA
- Spread: Panthers +1, Eagles -1
- Moneyline: Panthers -105, Eagles -115
- O/U: 42
The Panthers are on the road against the Eagles on Sunday afternoon. Carolina has a 2-2 record heading into this matchup, with wins against Atlanta and Detroit. The Eagles opened the season to consecutive wins, but have lost each of their past three games. See the latest Bryce Young odds and Jalen Hurts odds ahead of the game.
Bears vs. Falcons Odds, Spread, and Betting Lines
Date/Time: Oct. 18, 2026 | 1:00 p.m. ET
Location: Mercedes-Benz Stadium, Atlanta, GA
- Spread: Bears -3.5, Falcons +3.5
- Moneyline: Bears -180, Falcons +150
- O/U: 48.5
Chicago and Atlanta matchup in this Week 6 clash at Mercedes-Benz Stadium on Sunday. The Bears are 3.5 point favorites despite a 31-7 loss against Green Bay last time out. Atlanta also lost in Week 5, against the Ravens. See the latest Caleb Williams odds and Tua Tagovailoa odds ahead of the game.
Saints vs. Giants Odds, Spread, and Betting Lines
Date/Time: Oct. 18, 2026 | 1:00 p.m. ET
Location: MetLife Stadium, East Rutherford, NJ
- Spread: Saints -1, Giants +1
- Moneyline: Saints -115, Giants -105
- O/U: 45
New Orleans will be looking to snap a three-game losing streak against the Giants on Sunday. The Saints have lost against Minnesota, Atlanta, and Las Vegas in recent weeks. The Giants have a strong 3-1-1 record after five games. See the latest Tyler Shough odds and Jaxson Dart odds ahead of the game.
Steelers vs. Buccaneers Odds, Spread, and Betting Lines
Date/Time: Oct. 18, 2026 | 1:00 p.m. ET
Location: Raymond James Stadium, Tampa, FL
- Spread: Steelers -2.5, Buccaneers +2.5
- Moneyline: Steelers -150, Buccaneers +125
- O/U: 40.5
The Steelers are on the road against Tampa Bay in Week 6. Pittsburgh has lost both road games so far this season against Cleveland and New England, winning each of their three home games so far. The Buccaneers have a 1-4 record after Week 5 and are 2.5 point underdogs in this game. See the latest Aaron Rodgers odds and Baker Mayfield odds ahead of the game.
Jets vs. Patriots Odds, Spread, and Betting Lines
Date/Time: Oct. 18, 2026 | 1:00 p.m. ET
Location: Gillette Stadium, Foxborough, MA
- Spread: Jets +7, Patriots -7
- Moneyline: Jets +265, Patriots -340
- O/U: 44.5
The Patriots host the Jets at Gillette Stadium in this Week 6 matchup. The Jets ended a three-game losing run with a win vs. Cleveland in Week 5, while New England made it back-to-back wins with a 45-17 victory against the Raiders. See the latest Geno Smith odds and Drake Maye odds ahead of the game.
Titans vs. Colts Odds, Spread, and Betting Lines
Date/Time: Oct. 18, 2026 | 1:00 p.m. ET
Location: Lucas Oil Stadium, Indianapolis, IN
- Spread: Titans +7, Colts -7
- Moneyline: Titans +260, Colts -330
- O/U: 44
Tennessee will be searching for a first win of the 2026 season against the Colts on Sunday. The Titans have an unwanted 0-5 record ahead of this matchup. The Colts are 7 point favorites to win against Tennessee, despite their 34-22 loss vs. Pittsburgh in Week 5. See the latest Cam Ward odds and Daniel Jones odds ahead of the game.
Cardinals vs. Rams Odds, Spread, and Betting Lines
Date/Time: Oct. 18, 2026 | 4:05 p.m. ET
Location: SoFi Stadium, Inglewood, CA
- Spread: Cardinals +13, Rams -13
- Moneyline: Cardinals +550, Rams -800
- O/U: 52
The Rams host the Cardinals in this Week 6 clash on Sunday afternoon. Los Angeles posted the highest pre-season win total of any other franchise in pre-season, but has lost two of its opening four games. The Cardinals have a 1-4 record heading into this game. See the latest Matthew Stafford odds and Jacoby Brissett odds ahead of the game.
Bills vs. Raiders Odds, Spread, and Betting Lines
Date/Time: Oct. 18, 2026 | 4:25 p.m. ET
Location: Allegiant Stadium, Paradise, NV
- Spread: Bills -6, Raiders +6
- Moneyline: Bills -275, Raiders +220
- O/U: 53.5
The Buffalo Bills and Las Vegas Raiders will matchup at Allegiant Stadium on Sunday. The Raiders have made a strong start to the season, with a 3-2 record after five games. The Bills lost their first game of the season against New England in Week 4. See the latest Josh Allen odds and Kirk Cousins odds ahead of the game.
Chargers vs. Chiefs Odds, Spread, and Betting Lines
Date/Time: Oct. 18, 2026 | 4:25 p.m. ET
Location: Arrowhead Stadium, Kansas City, MO
- Spread: Chargers +8.5, Chiefs -8.5
- Moneyline: Chargers +325, Chiefs -425
- O/U: 42.5
The undefeated Chiefs host the winless Chargers in this Week 6 clash on Sunday afternoon. Kansas City has a 4-0 record heading into this game, after wins against the Broncos, Dolphins, Colts, and Raiders. Los Angeles are 8.5 point underdogs against the Chiefs after losing each of their opening five games. See the latest Justin Herbert odds and Patrick Mahomes odds ahead of the game.
Cowboys vs. Packers Odds, Spread, and Betting Lines
Date/Time: Oct. 18, 2026 | 8:20 p.m. ET
Location: Lambeau Field, Green Bay, WI
- Spread: Cowboys +0.5, Packers -0.5
- Moneyline: Cowboys -105, Packers -115
- O/U: 53.5
The Dallas Cowboys and Green Bay Packers matchup in this Sunday night game. The Cowboys have a 2-3 record heading into this game after a loss against Tampa Bay in Week 5. The Packers have won consecutive games against the Buccaneers and Bears in recent weeks. See the latest Jordan Love odds and Dak Prescott odds ahead of the game.
Commanders vs. 49ers Odds, Spread, and Betting Lines
Date/Time: Oct. 19, 2026 | 8:15 p.m. ET
Location: Levi's Stadium, Santa Clara, CA
- Spread: Commanders +7.5, 49ers -7.5
- Moneyline: Commanders +290, 49ers -375
- O/U: 50.5
The San Francisco 49ers will be aiming to continue their undefeated start to the season agianst Washington on Monday night. San Francisco posts a 5-0 record heading into Week 6. The Commanders' Week 5 tie against the Giants took their record to 1-3-1 after five games. See the latest Jayden Daniels odds and Brock Purdy odds ahead of the game.