Rays vs. Guardians ALCS Game 4 Odds & Betting Lines
The Tampa Bay Rays and Cleveland Guardians will go to head-to-head in Game 4 of the MLB American League Championship Series on Friday night. The game will kick-off at 8:00 p.m. ET, and will be played at Progressive Field. The Guardians lead the series 2-1 ahead of Game 4.
Below, you'll find the latest Rays vs. Guardians odds, spreads and betting lines at Fanatics Sportsbook, along with betting trends and additional game information. There's a wide range of MLB betting guidance, odds, and more at Fanatics Sportsbook.
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Rays vs. Guardians Matchup Information
Date: Friday, Oct. 16, 2026
Time: 68:00 p.m. ET
Location: Progressive Field, Cleveland, OH
TV: TBS
Rays vs. Guardians Odds
Tampa Bay is the slight -115 moneyline favorite against the Guardians at Fanatics Sportsbook, with Clevelabd -105 moneyline outsiders. Fanatics Sportsbook is offering point spread markets, totals lines, and prop markets for the game.
Rays vs. Guardians Moneyline Odds
- Rays Moneyline -115
- Guardians Moneyline -105
The above odds are correct at the time of writing, see below for live odds
Rays vs. Guardians Run Line Odds
- Guardians +1.5 -200
- Rays -1.5 +160
- Guardians +3.5 -575
- Rays -3.5 +390
- Guardians -1.5 +190
- Rays +1.5 -240
Rays vs. Guardians Total Runs Odds
- Over 6.5 -110
- Under 6.5 -110
- Over 9.5 +290
- Under 9.5 -400
- Over 3.5 -475
- Under 3.5 +340
Rays vs. Guardians +EV Bets
Below are the highest positive expected value bets for the Rays vs. Guardians game at Fanatics Sportsbook:
- Cleveland Guardians Moneyline -110 (EV 6.91%)
- Over 6 Total Runs -135 (EV 4.84%)
- Over 7 Total Runs +115 (EV 4.58%)
Rays vs. Guardians Odds FAQs
What are the latest odds for Rays vs. Guardians?
The Rays are moneyline favorites at -115, the Guardians are moneyline outsiders at -105. The run line is set at 1.5, with the over/under total runs line at 6.5 at Fanatics Sportsbook.
Who is favored to win Rays vs. Guardians?
The Rays are favored to win against the Guardians with moneyline odds of -130, which implies a 53.49% win probability.
What is the over/under total runs for Rays vs. Guardians?
The over/under total runs line for the Rays vs. Guardians at Fanatics Sportsbook is 6.5.
Where can I find the latest Rays vs. Guardians betting lines?
You can find the latest betting lines for Rays vs. Guardians at Fanatics Sportsbook. Fanatics offers moneyline, run line, and totals markets, as well as team and player prop betting options for every MLB game in 2026.